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paulalbert
Research Team
| Joined: | Fri Jul 16th, 2004 |
| Location: | New York USA |
| Posts: | 1023 |
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Posted: Mon Nov 15th, 2010 16:47 |
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| I could include such a section in the KB, but for some reason I'm disinclined to bother....
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Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
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Lottis
Health Professional
| Joined: | Sun Jan 21st, 2007 |
| Location: | Sweden |
| Posts: | 458 |
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Posted: Mon Nov 15th, 2010 16:51 |
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HTN,LVH,CHF,arrhythmia,hypercholesterol,IBS? fibromyalgia?salivarystones,gallstones,ect...|15feb-07 init. 1,25D 37,5,|25-D 7,8(latest 15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|
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ChrisMavo
Member
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Posted: Mon Nov 15th, 2010 18:14 |
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LMAO!!!
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PLS/ALS, speech difficulty, dizziness, leg weakness, overly emotional, Ph1Aug2609,11/2012 25D-12, 11/11: 25D-10, 04/11: 25D-11, 07/10: 25D-13, 05/10: 25D-15, 11/09: 25D-20, 9/09: 25D-27, 7/09: 25D-38, 1,25D-46, Mod Ph2Oct09, 100mg Mino
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Marysue
Foundation Staff
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Posted: Mon Nov 15th, 2010 18:21 |
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| Oh my, I'd be ROFL if I weren't so "lazy".
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MP Apr09 (no breaks)| CFS/FM,infert/endometriosis | hypotension, cardiac IP, chronic muscle/joint pain, neuro symptoms, severe light sensitivity | last 25D=12.5 Sep'11
Marysue on Benicar
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Aunt Diana
Support Team
| Joined: | Fri Sep 30th, 2005 |
| Location: | Boquette, Panama |
| Posts: | 1987 |
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Posted: Tue Nov 16th, 2010 08:16 |
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Thank you Dr. Marshall, for once again explaining how the system does (or does not) work. We are all so fortunate here to have access to true research that is not money motivated. I have to laugh when I think of my doctor wondering why there have been no "clinical trials" of the MP.
Maybe what he is really saying is where is my free trip to Hawaii? My husbands doctor recently admitted to him that he "no longer does that"...he only accepts a few meals a month from drug reps....and he brags about that fact.
Also, I am happy to report I have become one of the contented ones.....nothing seems to bother me anymore. Oh, is the volcano erupting?...how interesting.
A few years ago, "a mosquito is in the house!!! Help !"
My ability to withstand outside pressure situations is unlike any other time in my life.
What an interesting trip this has been.
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Lyme 1987, neuro cardio fatigue achiness brain fog depression, anxiety. Pacemaker, D.1,25 32; D <5; 12/07 <6, hydrocodone, lorazapam, benedryl, zantac, colase, Noirs, cover-up or avoid sun, house <30lux. Feb 08 Phase 3. 6/08 D <4, D1,25
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Lottis
Health Professional
| Joined: | Sun Jan 21st, 2007 |
| Location: | Sweden |
| Posts: | 458 |
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Posted: Wed Nov 17th, 2010 08:34 |
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Phillyguy wrote:
The PXR also transrepresses the androgen receptor, which is thought to express more antimicrobial peptides than any other receptor.
Phillyguy,
could you tell us some more about this and how it could apply to mental disorders?
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HTN,LVH,CHF,arrhythmia,hypercholesterol,IBS? fibromyalgia?salivarystones,gallstones,ect...|15feb-07 init. 1,25D 37,5,|25-D 7,8(latest 15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|
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Lottis
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| Joined: | Sun Jan 21st, 2007 |
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Posted: Sat Nov 20th, 2010 11:13 |
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I mean it is really interesting. 
| The androgen receptor is most closely related to the progesterone receptor, and progestins in higher dosages can block the androgen receptor.[8][9] |
http://en.wikipedia.org/wiki/Androgen_receptor
It hints to me that contraceptives could block this receptor, and I belive the Pill can cause high levels of free radicals, at least so I have heard by alternative medicin practioners. 
If this is true, contraceptives could disable the immune function of AR by blocking the productions of many antimicrobials. I guess it would contribute to high cholesterol as well.
And I know for sure that many women gets in a very bad mood whilst taking the Pill. I did suffer a lot the few times I tried it, or any other contraceptive with hormones actually.
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HTN,LVH,CHF,arrhythmia,hypercholesterol,IBS? fibromyalgia?salivarystones,gallstones,ect...|15feb-07 init. 1,25D 37,5,|25-D 7,8(latest 15/2-07)| Ph1 30/5-08|Olmesartan alone|NoIR's|covered up|disabled|
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Dr Trevor Marshall
Foundation Staff
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Posted: Sat Nov 20th, 2010 17:06 |
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the Pill can cause high levels of free radicals, at least so I have heard by alternative medicin practioners
Rule 1: Nearly everything that alternative medicine practitioners tell their patients is incorrect. Their model of the human body is ridiculously simplistic, even though it "sounds sensible." "Free Radicals" is a misleading concept which has not resulted in any useful therapies, ergo, it is almost certainly erroneous.
Rule 2. All the Type 1 nuclear steroid hormones interact with all the Type 1 nuclear receptors except for estrogen, which is well-targeted for the estrogen receptor(s) and the thyroid hormones, which are well-targeted for the the thyroid receptor(s).
Rule 3: Anything ingested or injected into the body is likely to affect the homeostasis of its metabolism.
Rule 5: The typical dose for thyroid hormone is a fraction of a milligram per day. You don't need much of a steroid hormone (or analog) to upset the human body. People who plaster 20mg of Progesterone on their skin "as a supplement" are asking for trouble, IMO. You cannot supplement hormones. The body regulates them... Just like Vitamin D...
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appledrummer
Member
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Posted: Sun Nov 21st, 2010 18:30 |
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Dr Marshall: If I may, I wanted to respond to several of the points you previously made in this thread.
People who plaster 20mg of Progesterone on their skin "as a supplement" are asking for trouble, IMO. I understand your concern, but there were two benefits of progesterone for me before I discovered the MP. I *may* never have had my second daughter if I had not had progesterone injections in the first trimester. There was also a strange precursor to my leap in understanding when I came across the science of the MP - I had been using progest cream to "relieve my symptoms" for a while because the blurb told me that it would reach receptors under the skin. If I had not read that I might have seen the MP site but ignored it.
Second, on becoming "driven" for a while then more laid back in recovery with the MP. I now recognise these patterns from the past - sometimes they have been over about five years, sometimes over a year. Although I have seen some big improvements this year I know I still have quite a way to go. I am now much more laid back, less anxiety, I tell my "do everything" friends to just chill out sometimes. But when another change in IP is about to crash in I seem to get between a week and a month of incredible drive - I write poetry, post repeatedly on my blog and embark on new projects! I was in one of those periods when I was able to meet you in London!
Thirdly: changes in appreciation of music. I have an autistic eldest daughter who has perfect musical pitch. In the year I took D-supplements out of our diet her cello teacher was baffled how for several months she kept playing out of tune. He kept telling her that he knew she could play a perfect note if she "tried" but I defended her, saying "She just seems to have a slightly different sensory awareness at times". Interesting that the guy mentioned who committed suicide had a diagnosis of schizophrenia. If I said to a psychiatrist today that I have a daughter who is quite confused right now, is happier with the music in her head than in playing her instruments, who is beginning to talk to an invisible person/herself a lot more than usual, and despite lots of normal behaviour learned over the last three years cannot make sense of social situations, I wonder what the on-the-spot diagnosis would be? Other than "she's going through her teenage years, of course!"
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Dx Fibromyalgia syndrome,depression w/chronic fatigue, photosensitivity. 2007/08 Cut D intake, NoIRs, avoided light. Started MP 2009. Stopped 2011. Restarted mid 2012 Olmesartan 4hrly, now plus NAC & cortef. Recovered better health
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun Nov 21st, 2010 19:14 |
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My medical research was whetted by our successful treatment of infertility with Gonadotrophin Releasing Hormone (GnRH). Here is a paper published by my group in 1981:
http://AutoimmunityResearch.org/transcripts/Keogh_Pulsatile_GnRH.pdf
and another, in Proc. Endocrine Society of Australia, 1982:
http://AutoimmunityResearch.org/transcripts/Keogh_Ovulation_Induction.pdf
We also had success with the exact LHRH hormonal analog in males:
http://www.ncbi.nlm.nih.gov/pubmed/6135766
There is a page at my website listing some of the other publications:
http://TrevorMarshall.com/gnrh.htm
So, you can see that I have seen more direct ways of dealing with infertility, other than the use of Progesterone. In the above cases the patients received a small pulse of the hormone (LHRH or GnRH) at a regular interval.
Sadly, the team leader, Ted Keogh, died in the mid-1990's and all our early discoveries disappeared into obscurity.
...until somebody came along with a pulsatile Olmesartan therapy called the Marshall Protocol ...
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appledrummer
Member
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Posted: Sun Nov 21st, 2010 19:59 |
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Very interesting to read, thanks! I am aware that the progesterone was a blunt instrument, and might not have worked. Your papers remind me how I researched a lot about US treatment for infertility and I remember reading about LHRH levels. My consultant was patronising and in the usual NHS way tried to turn me away, claiming there was nothing that could be done for such women. After I gave him an earful he immediately slid three prescriptions across the desk. Somehow I knew (as in several of those research case studies) that the Clomid (Clomiphene) would have no effect, so I never took it.
Now we have the MP, as you say! Thank you! (*All* I have to do is persuade friends with chronic illness and/or infertility that they can have their health restored, despite all the NHS docs telling them to take painkillers/ try again/see a counsellor. )
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Dx Fibromyalgia syndrome,depression w/chronic fatigue, photosensitivity. 2007/08 Cut D intake, NoIRs, avoided light. Started MP 2009. Stopped 2011. Restarted mid 2012 Olmesartan 4hrly, now plus NAC & cortef. Recovered better health
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titta
Health Professional
| Joined: | Wed Jul 4th, 2007 |
| Location: | United Kingdom |
| Posts: | 272 |
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Posted: Mon Nov 29th, 2010 20:12 |
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I am searching for studies and literature for my project to create a power point lecture about metagenomics and psychiatric diseases and the necessity for a translational approach (approximate title)
and I have found the following dissertation to gain a doctorate:
Inflammatory Monocytes in Bipolar Disorder and Related Endocrine Autoimmune Diseases by Roos Carlijn Padros, Erasmus university Rotterdam.
It is worth to be read as it explains the disease, the immune system etc etc in a rather clear language.
http://publishing.eur.nl/ir/repub/asset/14920/090225_Padmos,%20Roos%20Carlijn.pdf
Titta
As it is published in the internet I think I am allowed to inform you where to find it.
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MP start Jul'07 | Sarcoidosis
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ChrisMavo
Member
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Posted: Mon Nov 29th, 2010 21:39 |
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Excellent paper! I have skimmed the first few pages and find it fascinating. I have a daughter who was diagnosed as bi-polar years ago, so this if very pertinent to me.
Thanks for posting this!
Chris
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PLS/ALS, speech difficulty, dizziness, leg weakness, overly emotional, Ph1Aug2609,11/2012 25D-12, 11/11: 25D-10, 04/11: 25D-11, 07/10: 25D-13, 05/10: 25D-15, 11/09: 25D-20, 9/09: 25D-27, 7/09: 25D-38, 1,25D-46, Mod Ph2Oct09, 100mg Mino
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tussilago
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| Joined: | Fri Dec 18th, 2009 |
| Location: | Sweden |
| Posts: | 223 |
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Posted: Thu Dec 2nd, 2010 06:58 |
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Lottis sent me this link about schizophrenia and viruses and scientists who investigate the link between pathogens in the DNA and the development of disorders like MS, schizophrenia and bi-polar: http://discovermagazine.com/2010/jun/03-the-insanity-virus/article_view?b_start:int=3&-C=
ONe scientist cited says he has a sister who developed schizophrenia.
as I understood, some of the scientist cited changed focus from looking for a specific virus/pathogen to do a wide search for every pathogen- including those unknown to scientists- or traces from pathogens. Last edited on Thu Dec 2nd, 2010 07:05 by tussilago
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severe neuropsychiatric disease and borrelia antibodies | overwhelmed by symtom in 1996/97 | poor depth perception, dizzy, numb | no vitamin-D tests |Olmesartan since 1st of jan 2010
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ChristineL
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| Joined: | Fri Jan 2nd, 2009 |
| Location: | USA |
| Posts: | 38 |
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Posted: Thu Dec 2nd, 2010 15:31 |
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My medical research was whetted by our successful treatment of infertility with Gonadotrophin Releasing Hormone (GnRH). Here is a paper published by my group in 1981:
This is very interesting. Could Herxing that is affecting this hormone be the reason why after about a year on the MP, my menstrual cycle started to be 5-6 weeks long. I feel like my body is trying to ovulate at the appropriate time and tries again a week later and then again a week later. Once I finally do ovulate I feel soooo much better for the next two weeks and then I feel awful again until the next time I ovualate.
I also had a very early miscarriage one month prior to each of my two full term pregnancies.
Does this hormone have anything to do with hunger and blood sugar drops?
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Hashimoto, Graves, CFS like symptoms, synthroid reduce to 50mcg, light exp r/t work & w/kids, NoIRs always, ph1Nov08, ph2Jan08 // May09 stopped abx // March10 25D 9 & 1,25D 30 // June10 25D 16 & 1,25D 17// Feb11 25D 8
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seanlane
Member
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Posted: Fri Dec 3rd, 2010 03:41 |
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Great paper Titta.....if I were not in the middle of a big herx I would study it even more
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bipolar CFS neuropathy arrhythmia food sensitivities psoriasis MCS guillain-barre tinnitus 125D58 Ph1Jul/08 Ph2Oct/08 25D=17.8 Sept/08 25D=11.8 Jul/09 Ph3 Sept/09
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appledrummer
Member
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Posted: Fri Dec 3rd, 2010 12:16 |
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@Titta. A really excellent paper! Thank you for sharing.
@ChristineL. From your description it sounds very much like my own experience! Sometimes my cycle was as long as 5, sometimes 8 weeks, because I sensed that the ovulation was trying to sort itself it. Pre MP I also had blood sugar problems but the glucose tests never showed up anything. I note that NHS GPs are soon going to be asked to conduct different tests for diabetes as standard - it is anticipated that this might pick up double the number of diabetic patients. GPs responded in Pulse journal that this might cause them a problem in dealing with bigger caseloads - but of course this would help people like you and I.
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Dx Fibromyalgia syndrome,depression w/chronic fatigue, photosensitivity. 2007/08 Cut D intake, NoIRs, avoided light. Started MP 2009. Stopped 2011. Restarted mid 2012 Olmesartan 4hrly, now plus NAC & cortef. Recovered better health
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Dr Trevor Marshall
Foundation Staff
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Posted: Fri Dec 3rd, 2010 16:35 |
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Does this hormone have anything to do with hunger and blood sugar drops
ChristineL,
The body's hormonal homeostasis (balance) is complicated, but GnRH is not usually regarded as affecting insulin sensitivity or islet cell performance. However, the same microbiota which causes the imbalance in GnRH also causes diabetes. The human microbiota is complex, containing thousands of species, and the exact mix of species tends to change depending on the nutrient conditions in each tissue or organ.
Amy's presentation at Ljubljana gives a short introduction to our our new book chapter, which is a complete description of the processes involved.
http://www.youtube.com/watch?v=hO2YXh0ajnk
http://autoimmunityresearch.org/preprints/Proal_MHB_Chapter_preprint.pdf
It is important to remember that the VDR and Estrogen receptors are Yin and Yang - each transcribes each other, and the ligands for each other are different. As the MP balances the VDR metabolism, it also needs to find a balance for the estrogen metabolism.
One of our older papers deals with this issue in more detail:
http://autoimmunityResearch.org/preprints/ProalAnnals2009Preprint.pdf
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ChristineL
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Posted: Sat Dec 4th, 2010 11:50 |
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Thank you for your reply Dr. Marshall. I was asking because the severitly of the blood sugar crashes I experience before and/or after eating seem to correlate with my menstrual cycle.
It is important to remember that the VDR and Estrogen receptors are Yin and Yang - each transcribes each other, and the ligands for each other are different. As the MP balances the VDR metabolism, it also needs to find a balance for the estrogen metabolism.
So does trying to wean off synthroid cause upset to this balance as the body adjusts to new levels?
As I try to slowly wean off my TSH value is moving a bit higher (but not above 2 as of yet), but the Free T4 seems to stay at the high end of the lab range.
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Hashimoto, Graves, CFS like symptoms, synthroid reduce to 50mcg, light exp r/t work & w/kids, NoIRs always, ph1Nov08, ph2Jan08 // May09 stopped abx // March10 25D 9 & 1,25D 30 // June10 25D 16 & 1,25D 17// Feb11 25D 8
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seanlane
Member
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Posted: Sun Dec 5th, 2010 13:25 |
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As the MP balances the VDR metabolism, it also needs to find a balance for the estrogen metabolism.
Does this mean that there is ongoing research for potential future trials using another drug that would balance estrogen metabolism?
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bipolar CFS neuropathy arrhythmia food sensitivities psoriasis MCS guillain-barre tinnitus 125D58 Ph1Jul/08 Ph2Oct/08 25D=17.8 Sept/08 25D=11.8 Jul/09 Ph3 Sept/09
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