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wrotek
Member
| Joined: | Fri Dec 31st, 2004 |
| Location: | Wroclaw, Poland |
| Posts: | 1936 |
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Posted: Sat Jul 14th, 2012 23:49 |
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Experimental Therapy of Lyme borreliosis with
Granulocyte Colony-Stimulating Factor (Filgrastim)
page 56 http://www.lymenet.de/literatur/diterich.pdf
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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Paisleykilt
Member*
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Posted: Sun Jul 15th, 2012 00:38 |
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From Wiki: "Filgrastim is a granulocyte colony-stimulating factor (G-CSF) analog used to stimulate the proliferation and differentiation of granulocytes.[1] It is produced by recombinant DNA technology."
Yup, just had to read about 'filgrastim', because I hadn't run across it before in my Lyme research and now I've got that phrase 'recombinant DNA' stuck in my head again. Thanks, wrotek!
Is it possible that all you clever folks who read and understand these articles are posting them here in order to turn the rest of us into 'science nerds'? 
Must go do something artsy or start muttering words like 'eclectic' tout de suite! 
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MP start May'11 (no breaks) | Lyme Disease/CFS/Fibromyalgia (depending which specialist to believe) | muscle/joint pain, severe fatigue, neurological symptoms | last 25D= 11.2 ng/mL Jan.'13
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wrotek
Member
| Joined: | Fri Dec 31st, 2004 |
| Location: | Wroclaw, Poland |
| Posts: | 1936 |
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Posted: Sun Jul 15th, 2012 00:52 |
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I never liked biology 10 yrs ago, if i knew that i am learning this stuff so it could save my life someday. i would have had different attitude and payed more attention.
Last edited on Sun Jul 15th, 2012 00:53 by wrotek
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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leroybrown
Board Staff
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Posted: Sun Jul 15th, 2012 02:06 |
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I had G-CSF 20+ years ago when I was hospitalized with a fever of unknown origin (spiking to 106.2F every day for 2 months). It did nothing for me after 2 rounds of treatments. My WBC was close to zero. G-CSF is a biological I believe, and they give it to bone marrow donors. I recently read a horror story of a donor that had a bad reaction to it and was unable to work for 3 months.
Deb
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Life could be worse. Things could get bad. - Barney Bentall
Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
25D = 25 1,25D = 58 Aug 18/09|25D<4.8 Mar/10|10.8 Nov/12
Ph1: Sept 29/09 benicar q8hrs * Nov 26/09 q6hrs *
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun Jul 15th, 2012 02:49 |
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Folks, please understand that, on my first glance, there is nothing useful in this thesis. There are tens of thousands of scientists, who are each obsessed with studying a tiny part of the human metabolism -- each convinced that they have discovered something which is useful and important. I meet many of them as I travel from conference to conference.
So it is critical that we, as patients who have at least some idea of how our bodies work, that we wait until clear, definite, evidence of a breakthrough becomes available. The type of thing I would be looking for are a diverse group of people (such as we have here at the MP site) discussing that they are (generally and slowly) turning their back on chronic disease. When a breakthrough occurs you will be able to find that community.
Of course, there are thousands of "I am cured" reports on the Internet -- which disappear as you insist on meeting and evaluating these 'recovered' people. Often, as soon as I strike up an email conversation, I can make a reasonable assessment of whether any delusion or euphoria is coloring the perception of these folk.
The key is follow-up. What happens after the initial euphoria disappears... Recently a new therapy for CFS was declared successful/ It used infliximab to knock out B-cells. Great fanfare accompanied the over-sold claims of the scientists, but where are the people who actually are recovering their lives subsequent to this discovery? Heck, I haven't been able to find them. As far as I can tell, the researchers made a huge mistake in their understanding of what was happening. And this is far more common than any of us would realize 
So, Paisleykilt, you don't need to be a top-notch scientist to know what to do when you read reports such as Wrotek posted. Just chat with the people who have been cured as a result of the therapy (because few reports talk about endpoints other than 'cure'). Then pull that info back here to discuss it with our community. After all, one day there will be breakthroughs, and we will all be able to collectively celebrate
But individually we cannot expect to be able to match the collected wisdom of this community. In addition to my own perspective, we have the knowledge of my colleagues, and the knowledge of the whole community, to help us make an assessment.
Can I just make one plea. Please, please, do not assume that any breakthrough has occurred unless there are REAL PEOPLE involved. Medical research has progressed to the point where there is total anonymity for the cohort, and therefore it is possible for a researcher to conclude whatever they want to believe, and publish those false assessments to the world. The only thing that matters are the patients, and the degree to which they have recovered their lives.
..Trevor..
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