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Joyful
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Posted: Fri Feb 3rd, 2012 20:20 |
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Perhaps I'm not remembering correctly, but...
... didn't Sanko do STUDIES to show safety BEFORE the olmesartan medoximil was APPROVED by the FDA as safe?
Ok, I know it looks like I'm shouting, but I'm just trying to highlight something with that sentence. 
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Forums • Be Kind, We Are All Fragile • Conferences
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leroybrown
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Posted: Fri Feb 3rd, 2012 20:29 |
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Good luck Freddie!
Deb
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Life could be worse. Things could get bad. - Barney Bentall
Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
25D = 25 1,25D = 58 Aug 18/09|25D<4.8 Mar/10|10.8 Nov/12
Ph1: Sept 29/09 benicar q8hrs * Nov 26/09 q6hrs *
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pgeek
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Posted: Fri Feb 3rd, 2012 20:36 |
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Joyful wrote:
... didn't Sanko do STUDIES to show safety BEFORE the olmesartan medoximil was APPROVED by the FDA as safe?
They didn't need to show safety at 160mg/day, because the BP effect top out at ~40mg per day. (There was a very short trial on healthy volunteers at this sort of dose if I remember correctly. Otherwise high doses were only studied in animals - where they did indeed prove to cause very few problems.)
Most drugs have quite narrow therapeutic windows; I think this is why the gut reaction of many docs to problems in people taking MP doses of olmesartan is to blame the olmesartan.
Perhaps the ARF can commission a small study on this particular point, funds etc permitting. I know we have quite a bit of data from the cohort, but's difficult to get docs to accept it. Not least because IP can easily be confused with adverse reactions. A study with healthy volunteers ought to be able to clear this point up, removing an excuse for docs to deny us meds.
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Chronic Prostatitis, IBD(?)|Covered (+ ZnO in sun) |Sunglasses |25D: <4Jan12 (4Mar11/10Dec10/14Jan10| !!!COUCH MUSHROOM DESPERADO!!!
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Scarlett
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Posted: Fri Feb 3rd, 2012 21:01 |
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Freddie. . . So sorry to hear of your rx problems. Hope things smooth out for you soon. I remember fighting with my insurance company and how stressful it was so you take care of yourself. My best to you,
Scarlett
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MP March 2008 (No Breaks)/Sarcoidosis 2001 (skin, lungs, eyes), hypertension, Golbal Transit Amnesia 2007, Gastric Parethesis 2007, Migraines 2000, Severe Fatigue, Depression 1985, Osteoperosis and Osteopenia 2007 4/1/2011 25D<6
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Carricol
Support Team
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Posted: Fri Feb 3rd, 2012 21:22 |
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| We have enough stress just dealing with our illness and herxing issues. Things like this and uncooperative health care professionals just adds gasoline to the fire.
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Sarcoidosis, Arthritis, Fallen Arch, Vascular Insufficiency, fatty liver,diverticulosis, Fuchs Dystrophy, depression| 1,25D 16 (Oct08) | Ph1 Nov07, Ph2 Jan08, Ph3 May 09 Ben Only: Jun 10- Sep 10|Break Sep 10-Dec 10|Resume MP Dec 10|
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Freddie Ash
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Posted: Fri Feb 3rd, 2012 23:14 |
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HI
This is Fred in WV. I just want to say a great big thanks for all who has posted here in my support. I am sure I will get it worked out some way. It is a good thing that my family doctor gave me 56 Benicar on the 31st. I do have a few coming from Planet Drugs coming and should be here next week. This is a great group to help eacher. Again thanks to all.
I do think it is more about the money than my safety because why would they pay at the local drug store for the 3 pills per day.
Remember, we are all in this together and I am pulling for us.
Your friend in Sarcoidosis
Freddie
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Freddie: dx-sarc 2/82 lymph; skin, eyes, joints, esophagus, intestines, spleen, heart,lungs-25D-7; 125-D43
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Gerard
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Posted: Sat Feb 4th, 2012 19:11 |
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There is this study on long term safety and higher dose (1,5 - 5 times normal)
http://www.ncbi.nlm.nih.gov/pubmed/16601581
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MP start Jan'11 (no breaks) | rhinitis'78, sinusitis'78, COPD'82, asthma'82, eyes CSC left'86/right'99, hypertension,'99 hypercholesterolemia'03, legs varicose veins'03, tinnitus'05, hearing loss'05, BPH'06 | last 25D= 6 ng/mL Oct.2012
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pgeek
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Posted: Sat Feb 4th, 2012 19:26 |
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Great find! Here's the full text:
http://www.mediafire.com/?yaljcc2vxjibxxa
The study used candesartan for most subjects, but also various other ARBs (including a couple on olmesartan). So I think it's reasonable to generalise to the way we're using olmesartan.
This could be an extremely useful paper for people in Freddie's position; perhaps it should get a mention in the MPKB (if it's not in there already).
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Chronic Prostatitis, IBD(?)|Covered (+ ZnO in sun) |Sunglasses |25D: <4Jan12 (4Mar11/10Dec10/14Jan10| !!!COUCH MUSHROOM DESPERADO!!!
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Gerard
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Posted: Sat Feb 4th, 2012 20:02 |
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Hi Pgeek,
It's already in the MPKB see:
http://mpkb.org/home/protocol/olmesartan/safety
ref.8
Gerard
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MP start Jan'11 (no breaks) | rhinitis'78, sinusitis'78, COPD'82, asthma'82, eyes CSC left'86/right'99, hypertension,'99 hypercholesterolemia'03, legs varicose veins'03, tinnitus'05, hearing loss'05, BPH'06 | last 25D= 6 ng/mL Oct.2012
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pgeek
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Posted: Sun Feb 5th, 2012 07:19 |
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Gerard wrote:
It's already in the MPKB see:
http://mpkb.org/home/protocol/olmesartan/safety
ref.8
Hmm - not sure it's explained clearly enough there. Maybe I'll edit it and spell things out a bit...
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Chronic Prostatitis, IBD(?)|Covered (+ ZnO in sun) |Sunglasses |25D: <4Jan12 (4Mar11/10Dec10/14Jan10| !!!COUCH MUSHROOM DESPERADO!!!
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Freddie Ash
Member*
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Posted: Tue Feb 21st, 2012 00:03 |
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HI ALL
This is Fred in WV. When I try to bring up the 2 sites that Dr Marshall ask me to print for my doctor will not come up, only a blank page. I tried it 2 ways and just got the blank page both ways. So here I am asking for some help to bring up these sites so I can print them for my doctor. The sites are the ones in Dr Marshall's post on this site on Feb 3 at 14:41.
Remember, we are all in this together and I am pulling for us.
Your friend in Sarcoidsois
Freddie
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Freddie: dx-sarc 2/82 lymph; skin, eyes, joints, esophagus, intestines, spleen, heart,lungs-25D-7; 125-D43
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pgeek
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Posted: Tue Feb 21st, 2012 07:04 |
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Freddie Ash wrote:
HI ALL
This is Fred in WV. When I try to bring up the 2 sites that Dr Marshall ask me to print for my doctor will not come up, only a blank page. I tried it 2 ways and just got the blank page both ways. So here I am asking for some help to bring up these sites so I can print them for my doctor. The sites are the ones in Dr Marshall's post on this site on Feb 3 at 14:41.
Do you mean these ones?
http://autoimmunityresearch.org/abstracts/Ljubljana_Blaney_transcript.pdf
http://autoimmunityresearch.org/preprints/Proal2010CellularMolecularImmunologyPreprint.pdf
They're not websites, they're PDF files. To get them I think you can right click on the links and select 'save as' (or maybe 'save link as') Save them to the desktop, or at least remember where you saved them. THen you need a "PDF reader" to open and print them. You probably have 'Acrobat reader' in the programs section of your start menu.
Sorry that's a bit vague - someone using windows may be able to be a bit more specific. Let us know if you need a bit more help
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Chronic Prostatitis, IBD(?)|Covered (+ ZnO in sun) |Sunglasses |25D: <4Jan12 (4Mar11/10Dec10/14Jan10| !!!COUCH MUSHROOM DESPERADO!!!
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Dr Trevor Marshall
Foundation Staff
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Posted: Tue Feb 21st, 2012 22:46 |
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There is a free, safe, PDF viewer for Windows which can be downloaded from here, Freddie:
https://kjkpub.s3.amazonaws.com/sumatrapdf/rel/SumatraPDF-1.9-install.exe
This viewer is not susceptible to viruses, etc, although it will not always show complex forms properly. It will work perfectly with our own documents
Save the program to your disk, then run it -- it will install itself. You then will be able to view any files you have downloaded in PDF format.
..Trevor..
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scooker48
Member
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Posted: Sat Mar 23rd, 2013 15:40 |
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I attempted to re-order generic Benicar yesterday, 3/22/13, from Canadageneric.com with no success. They have changed their name, and wanted $1 a tablet.
I used planetdrugsdirect.com but they would not sell 270 tablets; the maximum they would sell was 180 of Benicar 40mg.
I am not happy.
Sherry
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D25, Total: 15 9/6/12
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John D
member
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Posted: Sat Mar 23rd, 2013 16:24 |
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Sherry,
Me not happy too!
I recently bought 180 x 40 mg Olmesartan for $102 from Planetdrugsdirect.com. ($.56 each)
I had to do a lot of back and forth with the nurses at docs office and also with Planet to finally get what I did. Ultimately Planet says they have legal limits to sell more than a six month supply(?) I tried hard to figure out how to get their best quantity and price, but had to settle for half that.
I hope Trevor posts on this page when his generic alternative is available.Last edited on Sat Mar 23rd, 2013 16:26 by John D
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Sarc- Lungs dx (biopsy)1985, pred 3yrs to 88. Begin MP:Feb/04 1,25D=58.1, 25D=18.1 Phase 2: June/04. Phase 3: Sept/04. Clean-up phase Oct/06. April/05: D1,25=13 25-D=6. June06: D1,25=31 25-D=11. Sept07: 25-OH D=18 Dec 2012 D1,25=43
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pgeek
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Posted: Mon Mar 25th, 2013 12:03 |
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Washington Goes for the Messenger: The US tries to cut off a lifeline for low-cost pharmaceuticals.
The issue of parallel trading seems to have reached the United States, where the US Justice Department has begun demanding that the two largest American couriers, FedEx and UPS, open and report on the contents in the sealed packages of their customers or face criminal charges.
At stake is the delivery of prescription medicines from online pharmacies to customers, according to a report last week by the online news portal WND. FedEx and UPS disclosed last November that they are targets of a federal criminal investigation related to their dealings with online pharmacies.
...
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Chronic Prostatitis, IBD(?)|Covered (+ ZnO in sun) |Sunglasses |25D: <4Jan12 (4Mar11/10Dec10/14Jan10| !!!COUCH MUSHROOM DESPERADO!!!
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GillyB
Member*
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Posted: Tue Mar 26th, 2013 03:43 |
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Oh, chunks. This is bad.
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MP start Jun'12 (no breaks) | Degenerative Disc Disease, Osteoarthritis | neuropathy, pain, loss of control of leg| depression, anxiety, fatigue, dizziness | olmecip 40q4hr, 25D history:7/12-12 ng/ml, 12/12-14 ng/ml
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scooker48
Member
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Posted: Tue Mar 26th, 2013 20:05 |
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| I checked and http://www.northwestpharmacy.com will sell 90 tablets for about $58.00 and yes...they will sell 270 with a doctor's Rx.
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D25, Total: 15 9/6/12
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jezzer
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Posted: Tue Apr 2nd, 2013 12:51 |
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| Anyone have experience of the brand Olmo-40 as its cheaper than Olmecip ?
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MP start October 2010 (no breaks). HYPOTHYROID + CFS for 25 years. key symptoms = fatigue, brain fog. 1st March 2012 - 25D = 9.16ng/mL / 7th March 2013 - 25D = 7.92ng/mL
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pgeek
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Posted: Tue Apr 2nd, 2013 12:57 |
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jezzer wrote:
Anyone have experience of the brand Olmo-40 as its cheaper than Olmecip ?
Is it much cheaper? (There's a brand called Olsertain that's about 1/2 the price of Olmecip in India, but otherwise all the Indian generics were similar prices last time I checked.)
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Chronic Prostatitis, IBD(?)|Covered (+ ZnO in sun) |Sunglasses |25D: <4Jan12 (4Mar11/10Dec10/14Jan10| !!!COUCH MUSHROOM DESPERADO!!!
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