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Big John
Guests visiting Phase 1/2/3
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Posted: Wed Oct 20th, 2004 07:13 |
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October 19, 2004, Day #27. Day #18 Mino.
Time 0730 BP 167/90. Pulse 91. Back to sleep.
Time 1500 BP 159/100. Pulse 81. Late last evening my hex waned. Took 37.5mg. Mino at noon today. This evening has been pretty much the calm before the storm. Unlike last dosage today was uneventful. Noticed slight dizziness, increased my eye drops, eyes were blurring out pretty good. Neck and shoulder pain is tolerable.
Time 2300 BP 156/98. Pulse 96. This evening brought a bit of eye pressure and tightness in the chest. Probiotic is helping with tummy gas. Eyes continue to be blurry. Returned to 1 hr. dosing of eye drops. Neck and shoulder pain has decreased. Got a strange burst of energy this evening and caught myself actually excited about cooking a meal. Seldom lately have I had any enthusiasm about anything. One of my main complaints about my disease has been my lack of motivation...
A GOOD DAY!
Last edited on Wed Oct 20th, 2004 07:13 by Big John
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Aussie Barb
Member in Phase 3
| Joined: | Thu Jul 22nd, 2004 |
| Location: | Australia |
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Posted: Wed Oct 20th, 2004 08:11 |
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Hi John 
RE: "Returned to 1 hr. dosing of eye drops. Neck and shoulder pain has decreased.
Got a strange burst of energy this evening and caught myself actually excited about cooking a meal. Seldom lately have I had any enthusiasm about anything. One of my main complaints about my disease has been my lack of motivation... "<<
I am wondering if there is any correlation between the eyedrop dosing & how you are...
when you decreased the eyedrop dose.... up went the herx..
when you increased the eyedrop dose again..... up went your energy..
perhaps you can watch for this.....  Best, Barb...
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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Big John
Guests visiting Phase 1/2/3
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Posted: Wed Oct 20th, 2004 18:53 |
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Hi Barb!
Yes thats right, I was thinking that also. when my eyes improbe I will attempt to verify our hypothisis. I really find it hard to understamd that drops instilled in the eye could be responsible for interfering with my herx, but I will test and see.
John
PS forgive my spelling I am pretty blind today!
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Reenie
inactive member
| Joined: | Wed Jul 21st, 2004 |
| Location: | Phoenix, Arizona USA |
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Posted: Wed Oct 20th, 2004 19:43 |
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Hi John,
As you and Barb try to figure out how your eyedrops affect your herx, I'm finding that weaning off of Cortef, (also a cortisone) seems to affect my herx too.
Supposedly, these subtle doses of cortisones aren't supposed to have an impact on our bodies, but apparently our bodies don't read the medical literature. 
Something else I'd like to add... "calm before the storm," you say, "got a strange burst of energy," IMO, this could be from:
1) slight increase in cortisone from eye drops, (I believe they're cortisone, right?)
2) increase in adrenaline due to the body's immune system working
CelticLadee noticed the wide awake feeling at night, which I've experienced too, from this. (my theory)
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Aussie Barb
Member in Phase 3
| Joined: | Thu Jul 22nd, 2004 |
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Posted: Wed Oct 20th, 2004 20:37 |
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Hi John
Re: > "I really find it hard to understand that drops instilled in the eye could be responsible for interfering with my herx,"<<
The eyes & skin are organs in our body as surely as any other.. what is absorbed is *in* there... wherelse could it go?  take care xx Barb...
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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Jill
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| Joined: | Sat Jul 17th, 2004 |
| Location: | Idaho USA |
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Posted: Thu Oct 21st, 2004 02:39 |
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I'm guessing you already know about reducing the systemic nature of eye drops? Just in case here it is: Immediately after putting the drop in the eye, close the lids, press your finger over the eye nearest your nose. Hold for 2 minutes. This keeps the drug from dripping down into your nose, throat, etc.
I do not think this is foolproof, I think some gets absorbed systemically, anyway. But worth a try?
I have to use pred eye drops too. so far haven't noticed much difference, but it could be a part of the big "mix" pics
Jill
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CFIDS20yrs, hypothyroid,iritis, neuropathy, hip joints; 9/11/01 25D32, 1,25D74
benicar 9/11/04 @40/6hr; mino start 10/20/04, now@50mg.
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Big John
Guests visiting Phase 1/2/3
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Posted: Thu Oct 21st, 2004 03:25 |
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Hi Barb and Reenie!
I like your new picture Reenie! Sexy!
I am not questioning that something instilled in an eye is absorbed. I do however find it hard to fathom that this little amount (as Reenie indicated) of cortisoid is interfering or maybe a better word is influencing my hex to this extent. I will have an answer before I am done though. Thanks for your input, as always very helpful!
John
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Big John
Guests visiting Phase 1/2/3
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Posted: Thu Oct 21st, 2004 03:28 |
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Hi Jill!
Thanks for your reply! Yes I have been told about the finger in the eye, However I still taste the drop when I do it, there for I am sure I am still getting some systemic absorbtion. I guess time will tell though!
John
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Aussie Barb
Member in Phase 3
| Joined: | Thu Jul 22nd, 2004 |
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Posted: Thu Oct 21st, 2004 03:48 |
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John not sposed to lick your finger  B...
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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Renee_RN
Health Professional
| Joined: | Thu Jul 22nd, 2004 |
| Location: | Michigan USA |
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Posted: Thu Oct 21st, 2004 04:45 |
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Reenie wrote:
When you get your Harley, maybe I'll be feeling well enough to ride mine again by then, too... itd, (in the dark) of course
Riding in the dark......
Reminds me of a political joke going around..... sorry couldn't resist~
Show your Support for your Choice of Candidate....
If you support John Kerry, please drive with your headlights on during the day on Saturday.
If you support George W. Bush, please drive with your headlights off Saturday night.
If you support Ralph Nader, please Ride your Bike on the center line of the road Saturday Day and Saturday night.
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Started MP 07.27.04
D Hydroxy 19.4 ng/mL (ref range 10-60)
D 1,25 Dihydroxy 34.2 pg/mL (ref range 25.1-66.1)
Dx: Chronic lyme, fibromyalgia,
Hx: CFIDS, IBD, IC. RSD. NMH, active CMV, EBV
Was bedridden 5 yrs, semi-functional past yr-2 w/ Zith. S
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Big John
Guests visiting Phase 1/2/3
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Posted: Thu Oct 21st, 2004 06:34 |
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October 20, 2004, Day #28. Day #19 Mino.
Time 0730 BP 160/99. Pulse 81. Back to sleep.
Time 1500 BP 165/96. Pulse 80. Today was not what I expected. Hex was minimal. Noticed sores inside my mouth, eyes continue to be blurry. Shoulder and neck stiffness were minimal, hip and knee pain seemed to be less today, go figure? Today was a Mino off day.
Time 2300 BP159/99. Pulse 76. Evening was pretty much uneventful, cramp in right calf lasted about 20 minutes, downed some cream. Neck stiffness continues to be minimal today, noticed a little anxiety this evening which hasn’t been present in several days. Energy level was good today and brain fog was minimal. My plan is to continue 37.5mg, Mino for at least a week, I will also continue Prednisolone eye drops for several days every hour.
A GOOD DAY!
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Big John
Guests visiting Phase 1/2/3
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Posted: Thu Oct 21st, 2004 06:42 |
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Reenie_RN
 My scooter doesn't have a headlight what am I supposed to do?
Guess I will spend Saturday & Sunday praying that whoever gets in makes the right decisions..
John
Last edited on Thu Oct 21st, 2004 06:43 by Big John
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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bpeck
Banned
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Posted: Thu Oct 21st, 2004 18:03 |
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John:
I'm assuming your eye drops are Pred-Forte.
These are absorbed systemically. Information as per my Ohpthalmologist:
2 drops every 2 hr around the clock will result in the same as taking 5 to 7 milligrams of prednesone orally.
So yes. IMO this could affect your immune system if you are using them often- which will affect herxing, and killing of pathogens.
BPeck
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Reenie
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| Joined: | Wed Jul 21st, 2004 |
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Posted: Fri Oct 22nd, 2004 01:30 |
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Barb,
Where did your Opthalmologist get this information or is it his/her own "analogy"?
It seems to me, Drs spout out many a comment w/o actual basis for factual info. OTOH, there may be merit to your Dr's comments.
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Big John
Guests visiting Phase 1/2/3
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Posted: Fri Oct 22nd, 2004 20:44 |
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October 21, 2004, Day #29. Day #20 Mino.
Time 0730 BP 165/96. Pulse 80. Back to sleep.
Time 1500 BP 147/89. Pulse 101. Took 37.5mg. Mino at noon. Sinus began to open about 1400. Increase in stomach discomfort, took probiotic. Cramp in toes & calf last night, had to get up and walk them out.
Time 2300 BP 160/99. Pulse 81. Tonight was quite uneventful, slight pressure behind my eyes and lots of tummy gas. I definitely notice when I have a high sugar meal or snack that my gas increases. Likewise if I have a high protein, low carb meal then I am much more comfortable and less bloated. Makes a big difference. Hip and knee pain is about normal, neck pain is much more noticeable Tylenol help.
A GOOD DAY.
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Aussie Barb
Member in Phase 3
| Joined: | Thu Jul 22nd, 2004 |
| Location: | Australia |
| Posts: | 19553 |
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Posted: Sat Oct 23rd, 2004 01:00 |
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John Thanks for posting >> My 30 Day Review interesting summary... Barb
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Barb: Dx Inflammatory Disease Endocrine Imbalance 2003| Depression| 24+ years not Dx| MP Aug04| ABC of MP| MP Search|
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Big John
Guests visiting Phase 1/2/3
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Posted: Sat Oct 23rd, 2004 07:50 |
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October 22, 2004, Day #30. Day #21 Mino.
Time 0730 BP 159/99. Pulse 76. Back to sleep.
Time 1500 BP 160/95. Pulse 93. Today was an off Mino day. Upon awakening I was quite surprised to find my right knee and hip without pain. This only lasted about an hour, but it was great! This is the second time I have been aware of this in the last 2 weeks. Dare I hope? Anyway everything else is about the same. Eyes continue to be blurry.
Time 2300 BP 156/100. Pulse 91. This evening eyes continue to blur, neck stiffness has increased a bit, although bearable. I baked much of the afternoon so hip and knee are a bit tender. Energy level today was pretty good, fatigue was absent today. When these eyes clear up I will really get excited.
A GOOD DAY!
____________________
Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Big John
Guests visiting Phase 1/2/3
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Posted: Sun Oct 24th, 2004 06:29 |
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October 23, 2004, Day #31. Day #22 Mino.
Time 0700 BP 160/95. Pulse 73. Back to sleep.
Time 1500 BP 158/108. Pulse 98. Took 37.5mg. Mino at noon. Pretty much uneventful day, pain was normal, although I am waking with less pain what I called morning stiffness. Energy level is still good, although I tire fast when doing something, energy level returns quite fast.
Time 2300 BP 156/100. Pulse 91. Evening brought neck and shoulder pain. Slight brain fog today too. Energy level remained this evening. Eyes still blurry. No leg cramps today! Tummy gas & chest discomfort noticeable, hip & knee pain is normal.
DAY
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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Big John
Guests visiting Phase 1/2/3
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Posted: Mon Oct 25th, 2004 09:18 |
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October 24, 2004, Day #32. Day #23 Mino.
Time 0700 BP 156/100. Pulse 91. Back to sleep.
Time 1500 BP 139/84. Pulse 93. Woke today pretty stiff and sore in right knee and hip. Neck was quite stiff too. Eyes were blurry and sore. Increase in dizziness.
Time 2300 BP 151/89. Pulse 80. Evening brought increased pressure behind eyes, knee and hip continue to hurt. Eyes were blurry all day. Dizziness abated around 1800. Neck pain continues. Several friends report they noticed I have had more energy. I tend to agree, last several days things are definitely changing a bit. Must be about time to ramp up. Going to stay at 37.5mg. Mino for several days though, have some stuff I need to get done, can use the energy.
Day
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Reiters Syndrome, Benicar 9/23/04. Mdx: Sotolol, atenolol, spironolactone, amlodipine,alprazolam, lexapro, Benicar q8. Ph2 12/05. Ph3 5/06
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bpeck
Banned
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Posted: Mon Oct 25th, 2004 19:44 |
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Reenie:
No he wasn't guessing.
There is supporting data about the systemic absorption of just about any substance used topically (including the eye) - mainly done to find out what pregnant and nursing mothers can and can't use while nursing.
BPeck
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