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Posted: Fri Oct 29th, 2004 04:15 |
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Why do I feel better in the summer? And worse in the winter?
Chronic Th1 inflammation causes your Vitamin D metabolism to become dysregulated. Your kidneys which are the source of 1,25-D normally, are no longer able to control the amount of 1,25-D that is produced. Your inflammatory tissues are producing 1,25-D also without any limiting control by your kidneys. The resulting abnormally high level of 1,25-D is a tactic used by the bacteria to maintain a favorable cellular environment.
Normal people either do not have the triggering bacteria, not enough bacteria to cause a problem yet, or they have an immune system that is able to recognize these invaders and kill them. Normal people can lie in the sun all day without an increase in 1,25-D because they do not have Th1 inflammation and their kidneys limit the amount of 1,25-D that is produced.
Because you typically get more sun exposure in the summer, your inflammatory tissues will produce more 1,25-D. The consequent increase in 1,25-D 'paralyzes' your immune system. It allows the bacteria to enter the cells at will and multiply. The immune system is less able to kill them. When bacteria are not being killed, you don't have the added symptoms of a Herxheimer reaction.
Your increased symptoms in the winter are due to the fact that your 1,25-D has come down a bit with less sun exposure and your immune system is better able to kill the bacteria. When bacteria are being killed, you feel worse because of the Herxheimer effect.
Trevor has said,
"In order for your immune system to be able to recognize, and start to kill, the intra-phagocytic bacteria, your Vitamin D metabolites have to be low. How low? We just don't know. But each person can sense the point at which their bodies start to kill the bacteria because they become sensitive to light and more sensitive to the protein-synthesis-blocking antibiotics used in the Marshall Protocol.
We have shown that the ARBs, as a class, have a wide range of activity in the Nuclear Receptors, quite distinct from their intended target, the Angiotensin II receptor. The Nuclear Receptors are responsible for transcription of genes which are active in the immune system. Others have now confirmed my work on PPAR activity, and I have gone on to specifically show that Benicar is a strong agonist of the VDR nuclear receptor, which is at the heart of innate immunity.
However, one feels better when the bacteria are not being killed, and folks often feel better when their D metabolites are high. This is at the expense of an eventual relapse, as not even the Marshall Protocol antibiotics taken during this time will help the body to start killling the bacteria."
The fluctuation of hormones in the person with Th1inflammation due to any change of light, season or stress etc is likely to create a change in immune system response and/or symptoms.
See also:
The Effect the Effect of Sunlight/Daylight and Bright Lights on Persons With Th1 Inflammatory Disease
Won't avoiding the sun increase my depression?
Vitamin D Tutorial Calciferol and Calcitriol
A Review - Vitamin D and Calcium in Sarcoidosis (7-5-03)
http://www.sarcinfo.com/calcium.htm
link to Review of Vit D and Dr Marshall comment
Why are so many doctors ordering Vitamin D supplementation?
Avoiding Sunlight and Bright Lights
Incident Radiation Tutorial
Testimonials to the Need to Avoid Light
Protecting Your Eyes
Dr. Marshall has created a diagram summarizing some of the key relationships between the body's hormones and 1,25-D.
You can access it at
http://autoimmunityresearch.org/hormones.pdf
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