What effect would concurrent viral and CWD bacterial infections have on 1,25-D?
While intracellular bacterial infection causes elevated 1,25-D, viral infections cause 1,25-D to drop very low. If you have concurrent CWD intracellular bacterial and viral infections, your 1,25-D may test in the average range.
In other words, the virus causes 1,25 to drop while the bacteria causes it to rise, canceling each other out as it were. In this case, the fact that 1,25-D tests “average” really means it is depressed because of what the viral activity is doing to it. This can be confirmed by viral testing if necessary. It should be suspected when the clinical picture indicates Th1 inflammation but the D tests results are equivocal.
Dr. Marshall says, "Once the Th1 pathogens are killed off the immune system will likely handle the viral pathogens on its own; they are merely co-infections."
This article of Dr. Marshall in CHEST explains the continuum of the Th1 Th2 processes (look towards bottom of article)
This paper discusses AIDS and 1,25-D:
Severe Deficiency of 1,25-Dihydroxyvitamin D3 in Human Immunodeficiency Virus Infection: Association with Immunological Hyperactivity and Only Minor Changes in Calcium Homeostasis
Charlotte J. Haug, Pål Aukrust, Egil Haug, Lars Mørkrid, Fredrik Müller and Stig S. Frøland The Journal of Clinical Endocrinology & Metabolism Vol. 83, No. 11 3832-3838 Copyright © 1998 by The Endocrine Society
====================================
The 1,25-D drops if a Th2 reaction is dominant, thus inhibiting the body's ability to mount a Th1 defense.
Neither EBV or HHV-6 are powerful enough pathogens to lower the 1,25-D very much, based on the data I have seen.
Remember that a good Th1 response can be mounted down to about 12 pg/ml of 1,25-D
..Trevor..
ps: the D ratio is an aid, a tool, and it fails with extremes of data. Just like most tests in medicine have to be interpreted in conjunction with other signs and symptoms 
Oct 08....The reason that people with Th1 infection do not 'get colds', is because the symptoms of colds are now believed to come from the immune system fighting the virus. If your immune system is comprised, there will be no fighting, and no symptoms.
http://www.sciencedaily.com/releases/2008/10/081029101201.htm
Does the virus accumulate in a Th1 body over time? The best answer to that is -- probably ..Trevor..
Last edited on Thu Nov 6th, 2008 19:24 by Foundation Staff
|
