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Jvancan
Member in Phase 3
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Posted: Mon Oct 3rd, 2005 09:24 |
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I tought this would be interesting to post. Because as I am wright, Dr. T. Marshall did the same school as Barry Marshall.
http://nobelprize.org/medicine/laureates/2005/index.html
and
http://nobelprize.org/medicine/laureates/2005/press.html
The Nobel Prize in Physiology or Medicine 2005
The Nobel Prize in Physiology or Medicine 2005 goes to Barry J. Marshall and J. Robin Warren "for their discovery of the bacterium Helicobacter pylori and its role in gastritis and peptic ulcer disease".Last edited on Mon Oct 3rd, 2005 09:27 by Jvancan
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Lyme 125D69 25D32 Ph1May 06 Ph2July06 Ph3Dec06 break Mar07 to Jan08 25D12.6Jan08 NoIRs occ lite exp Ph1Jan08 Ph2Apr08
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Dr Trevor Marshall
Research Team
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Posted: Mon Oct 3rd, 2005 10:43 |
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Yes, Barry graduated MD from the same university that I graduated with my PhD. We both did clinical research at the same 'QEII Medical Centre,' under many of the same mentors.
I never met Barry, though, as I moved to the USA in 1982, before his breakthrough became widely known (circa 1985).
The atmosphere at QEII Medical Center in those days was an exciting 'can do' atmosphere. I had the good fortune to research with Dr. Ted Keogh (tragically, he died young in circa 1995). Our group developed a pulsatile infusion for the treatment of Cryptorchidism without surgery (http://tinyurl.com/6yx54 ) and also cured both male and femal infertility with pulsatile infusion of the Gonadatrophic hormone GnRH.
http://www.trevormarshall.com/gnrh.htm
Sadly, these technologies have been lost in the mists of time, and young kids today are still subjected to surgery, even though the non-invasive systems we developed had worked so well.
Later I studied at Hospital for Sick Kids in Toronto, where I did most of my work on Diabetes, the work which formed the basis of my thesis.
http://tinyurl.com/536u8
http://tinyurl.com/cu44a
It is good to see Barry get this award, although, as is the case with most Nobel prizes, this recognition has taken 20 years in fruition.
The fascinating thing is that many of the patients whom we were treating for infertility were suffering from Th1 diseases (eg: Anorexia Nervosa). Nowadays I can look back and see that we were probably just rebalancing their Gonadatrophic hormones for the effects of 1,25-D (just as our hormones chart portends). It has taken 25 years to get to this understanding, let's hope it doesn''t take another 25 years to break into the consciousness of the medical 'status-quo.'
Congratulations, Barry, congratulations UWA, congratulations QEII Medical Center!
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alayne
Member in Phase 3
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Posted: Mon Oct 3rd, 2005 17:52 |
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Hi all, I just saw this in the NY Times and think it's wonderful. It's not about MP directly, but should hopefully have an effect on the medical world's ability to open its eyes a little more widely to bacterial pathogens causing chronic disease. I hope it's okay that I copied and pasted the article.
I will be alive and healthy when Dr. T. Marshall wins his. I very much look forward to that day.
Australians Receive Nobel for Bacterium Work
By LAWRENCE K. ALTMAN
Published: October 3, 2005
Two Australian scientists who discovered a bacterium that causes stomach inflammation, ulcers and cancer won the 2005 Nobel Prize for Physiology or Medicine today.
The winners were Dr. Barry J. Marshall, 54, a gastro-enterologist from Nedlands, and Dr. J. Robin Warren, 68, a pathologist at the Royal Perth Hospital in Perth.
A famous experiment that Dr. Marshall made on himself was crucial in linking the bacterium and inflammation of the stomach, or gastritis.
Their findings in the early 1980's so upset medical dogma, which held that psychological stress caused stomach and duodenal ulcers, that it took many more years for an entrenched medical profession to accept it.
In its citation, the Nobel committee from the Karolinska Institute in Stockholm said that Dr. Marshall and Dr. Warren had "made an irrefutable case that the bacterium Helicobacter pylori" causes the ulcers and other disease.
At the time the Australians were making their findings, doctors could heal ulcers with drugs that blocked the production of gastric acid, but the ulcers often relapsed because the bacteria remained to perpetuate inflammation.
With the Australian finding of the spiral shaped H. pylori bacteria, ulcers are no longer a chronic disease. Doctors can cure most stomach and duodenal ulcers, the stomach irritation (gastritis) that leads to ulcer formation, and many stomach cancers.
"It is now firmly established that H. pylori causes more than 90 percent of duodenal ulcers and up to 80 percent of gastric ulcers," the Nobel committee said.
The inflammation produced by H. pylori can also cause stomach cancer and seems to be prevented by antibiotic treatment of the bacteria. In the early 20th century, stomach cancer was a leading cause of cancer in the United States. But its incidence declined substantially before the discovery of H. pylori's role. Stomach cancer remains the second leading cause of cancer deaths worldwide.
H. pylori also plays an important role in a type of lymphoma cancer of the stomach known as MALT, for mucosa associated lymphoid tissue. Such lymphomas usually regress when antibiotics rid the stomach of H. pylori.
Since the late 1800's, a number of doctors noted the presence of the curved bacteria in the stomachs of patients with ulcers and gastritis, but they ignored the connection.
In the 1980's, Dr. Warren noted the bacteria in the lower part of the stomach in about half the patients from whom biopsies had been taken. He made a crucial observation that signs of inflammation were always present in the surface lining of the stomach near where he observed the bacteria.
Dr. Marshall joined Dr. Warren in studying biopsies from a series of patients and Dr. Marshall succeeded in growing a then unknown bacterium that he thought was a member of the Campylobacter family. It was later renamed H. pylori.
Dr. Marshall has said that he was aided in the discovery by working in an academically obscure location where he could keep an open mind on pursuing his observations.
"If I had come up through the normal gastro-enterology training schemes in the United States, I would have been so indoctrinated on the acid theory that I wouldn't have been considering anything else and might have skipped over Helicobacter, as everyone else had done," Dr. Marshall said in a telephone interview today. "Robin is quite obsessional. Once he sees something, he's determined to see what itis. He would have found another Barry Marshall" to make the discovery.
In the wake of the ulcer discovery, many scientists are seeking unknown infectious agents as the cause of many chronic diseases. Examples are microbes that might produce atherosclerosis, the underlying basis of coronary artery disease, and other chronic ailments like ulcerative colitis, regional enteritis, also known as Crohn's disease), and rheumatoid arthritis.
Alayne adds: Sarcoidosis, Lupus, CFIDS, and so on and so on.
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ME/CFS/FM 6/05:25D-34 1,25D-69, 11/07:25D-8 1,25-37, Sick 6-11 mos/yr x20+yrs. NoIRs/Avoid Sun/D/Use Zinc oxide. 11/17/05-Ph1, 5/06-MPh2, 12/06-MPh2#2, 6/07-MPh2#3,1/08-Ph2, 4/08-Ph3, NonMP Meds:Sleep:1-2mgLoraz or OTC q2d/MThistle/Calc&Mag/Lysine
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BARNEY
Member in Phase 3
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Posted: Tue Oct 4th, 2005 10:30 |
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Trevor,
On my trip home from Bethesda, I sat next to a young man from China who is studying to be a PHD (medical research). I let him read the papers you had given me and his comment when he finished reading them was:
If this is true and really works, Dr Trevor G. Marshall, will someday in the future, win a Nobel Prize.
My comment:
It is very true and I am here to show you it does.
Then, on the next (last) plane, the man who sat next to me was a former Army Medic and before I could get the word BACTERIA out of my mouth, he said it. I asked how he knew and he said BECAUSE IT MAKES SENSE.
Barney
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64jointsarc77skinsarc80lungsarc81asthma/migranes
95rkidneyremoved(cyst)diabetic/gallbremoved,96
totalhyst(cysts,endom)01fibro,Benicar20mg@3hrs, xtra as needed, Mino25mg @other day
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Dr Trevor Marshall
Research Team
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Posted: Tue Oct 4th, 2005 17:57 |
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Here is the story from a slightly different perspective (that of the newspaper 'The Australian')
http://tinyurl.com/96aps
Liz worked at Fremantle Hospital for much of our 8 years in Perth, and at Royal Perth Hospital for a short time. She doesn't remember Dr Warren, though.
Note that this research was unfunded, in the spare time of the scientists. That's the way we used to do things back then...
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BARNEY
Member in Phase 3
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Posted: Tue Oct 4th, 2005 18:21 |
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Gee Trevor,
That almost sounds like how Marshall Protocol is going to be down the road. They may laugh at us now, but they will realize you are right and it works.
Barney
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64jointsarc77skinsarc80lungsarc81asthma/migranes
95rkidneyremoved(cyst)diabetic/gallbremoved,96
totalhyst(cysts,endom)01fibro,Benicar20mg@3hrs, xtra as needed, Mino25mg @other day
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Nightshade
Guest
| Joined: | Mon Jul 4th, 2005 |
| Location: | Berlin, Germany |
| Posts: | 82 |
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Posted: Fri Oct 14th, 2005 06:15 |
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Barney,
The nobel price is a question of time. The work of Barry Marshall and Trevor Marshall has much similar points. Both discovered pathogen bacteria that
- live in an environment designed to kill them (stomach acid or inside immune cells)
- cause diseases not recognized yet as an infection
- were seen but ignored by others before
And both used themselves as guinea pigs, both were first neglected by established medicine, both made severe chronical diseases curable.
The observations that do not fit in the theories (or rather the dogma), that can not be or are not allowed to be are the fuel on which science runs. The medicine establishment feels so unwell with Trevor Marshall because he did the work they failed to do even when their heads were bumped into the facts. Can you imagine how emberassing it is when you searched a place again and again for traces of gold dust, found nothing and later someone finds nuggets bigger than melons there?
Nightshade
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MP: Age 33 Borreliosis 83? dx 02, Brain fog, tiredness, depress, arthrit knees hands, Headaches. started Benicar 11.11.05 Mino 27.11.
25D=20; 1,25D=27 NOIRs avoid Light/VitD
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BARNEY
Member in Phase 3
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Posted: Fri Oct 14th, 2005 09:48 |
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Nightshade,
It is really great to be part of history, isn't it?
Getting to spend time with Trevor has been fantastic. Everything seems so easy when he explains it to you. When you are with him, he is just like opening a book of wisdom.
HANG IN THERE, WE WILL MAKE IT!!! BARNEY
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64jointsarc77skinsarc80lungsarc81asthma/migranes
95rkidneyremoved(cyst)diabetic/gallbremoved,96
totalhyst(cysts,endom)01fibro,Benicar20mg@3hrs, xtra as needed, Mino25mg @other day
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paulalbert
Board Staff
| Joined: | Fri Jul 16th, 2004 |
| Location: | USA |
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Posted: Tue Dec 6th, 2005 19:55 |
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Today's NYTimes has an article about a Dr. Freedberg who posited a connection in an eminent journal between a kind of curved bacteria (later identified as H. pylori) and stomach ulcers way back in 1940.
According to the article, no one at the time was able to replicate Freedberg's work much less culture the bacteria in a petri dish. Freedberg's colleagues at Harvard-affiliated Beth Israel Hospital in Boston strongly discouraged him from pursuing this idea.
I take away two lessons here:
1. Just because it can't be cultured outside the body, doesn't mean it is not a viable organism within the body.
2. It is not enough to be right. The successful dissemination of an idea in medicine sometimes depends on a little bit of pigheadedness.
Paul
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Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
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