 |
| Author | Post |
|---|
Lee
Member in Phase 3
|
Posted: Fri May 9th, 2008 14:11 |
|
Culprit found for Jaw Decay Linked to Bisphosphonates
Posted By admin On May 4, 2008 @ 3:37 pm In Restorative, What's New | 2 Comments
A group of University of Southern California School of Dentistry researchers says it has identified the slimy culprits killing the jawbones of some people taking drugs that treat osteoporosis.
Microbial biofilms, a mix of bacteria and sticky extracellular material, are causing jaw tissue infections in patients taking bisphosphonate drugs, said Parish Sedghizadeh, lead researcher and assistant clinical professor at the USC School of Dentistry.
Sold under brand names such as Fosamax, Boniva and Actonel, bisphosphonates are prescribed to millions of patients to combat osteoporosis, a bone-wasting disease that increases the risk of fractures.
Sedghizadeh said there have been increasing reports of osteonecrosis (bone death) of the jaw in patients who have been taking the drugs for osteoporosis or for treatment from the bone-wasting effects of cancer. He said he decided to investigate further after seeing patients in USC dentistry clinics who had the unusual jaw infection.
“This is the first study that identifies microbial biofilms in the bone of bisphosphonate patients who have osteonecrosis of the jaw,” Sedghizadeh said.
Jaw osteonecrosis occurs when bacteria-laden biofilms infect the jaw after the bone is exposed, typically because of a tooth extraction or injury.
The USC research team includes renowned biofilm expert J. William Costerton, director of the Center for Biofilms at the USC School of Dentistry.
Pioneered by Costerton, biofilm theory has moved scientists beyond thinking of bacteria as free-floating organisms. Instead, bacteria build biofilm communities, attaching to surfaces and communicating and defending against antimicrobial invaders.
The team used powerful scanning electron microscopes to study patients’ jawbone samples. The images revealed biofilm bacteria sprawling over pitted tissue.
The scientists are now trying to determine why bisphosphonate drugs seem to open the door for biofilm-associated infections of the jaw.
“Now that we’ve know biofilms are behind the infection of the jaw, we are studying ways to effectively treat or prevent the osteonecrosis,” Sedghizadeh said.
Source:
Contact: Angelica Urquijo
University of Southern California
____________________
2003 SARC w/COPD
D ratio-2.13 Ph1-2/05 Benicar| 4/05 PH2| 06 Ph3| D25=5.4 2007-TSH-0.09 probiotics/silymarin/sunlight w/noirs
|
NorCalJim
Member in Phase 3
|
Posted: Fri May 9th, 2008 15:33 |
|
It seems like biofilms are being implicated in more and more conditions all the time. I recently found an article in Science Daily reporting that persistent biofilm bacteria are now also suspected in chronic ear infections (which I have alot of personal experience with.) I found this quote particularly interesting:
"It appears that in many cases recurrent disease stems not from re-infection as was previously thought and which forms the basis for conventional treatment, but from a persistent biofilm,"
Here's a link to the full story if you're interested: http://www.sciencedaily.com/releases/2006/07/060712075834.htm
NorCalJim
____________________
Ankylosing spondylitis Ph1Mar07 Ph2Jun07 Ph3Nov07, no other meds or supps 25D18 (May07) 25D16 (Feb08) NoIRs in/out cover up out
|
Markt9452
Member in Phase 2
|
Posted: Fri May 9th, 2008 19:20 |
|
It looks like the Scientists are starting to catch on to the concept of Bio-film.
Here is another article about the latest Superbug Stenotrophomonas maltophilia out today.
http://www.metro.co.uk/news/article.html?in_article_id=146311&in_page_id=34
Steno sticks to catheters or medical tubes and grows into a so-called 'biofilm'. When the catheter is next flushed, the bug enters the patient's bloodstream and can cause septicaemia, especially if their immune system has already been weakened."
____________________
Th1 Inflammation Lyme vertigo fatigue brain fog skin lesions tinnitis 125D20 D2510 Ph1Feb08 Ph2Apr08 daily lite exp covered up NoIRs
|
Current time is 23:19 | |
|
|
|
|
