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Dr Trevor Marshall
Foundation Staff
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Posted: Sat Feb 21st, 2009 18:52 |
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Over the last several months, my colleagues and I have been frantically writing (and editing) (and revising) papers which we were invited to write after the successful presentations in Portugal.
Two papers have just been published on Elsevier's website:
Proal AD, Albert PJ, Marshall TG. Autoimmunity in the Era of the Metagenome. Autoimmunity Reviews, in press.
http://dx.doi.org/10.1016/j.autrev.2009.02.016
A full-text preprint is available from:
http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf
and
Albert PJ, Proal AD, Marshall TG. Vitamin D: The alternative hypothesis. Autoimmunity Reviews, in press.
http://dx.doi.org/10.1016/j.autrev.2009.02.011
A full-text preprint is available from:
http://AutoimmunityResearch.org/transcripts/AR-Albert-VitD.pdf
There are still 3 papers "in press" at the Annals of the New York Academy of Sciences. They have been peer reviewed and accepted, but are awaiting publication in the special issue "Frontiers in Autoimmunity." There is also still a paper in gestation, which has not yet been submitted.
I am sure you will realize that these two papers embody the very latest elements of our scientific knowledge, and will make a huge difference to the way that the public (and your Doctors) view our work. My sincere thanks go to Amy, Paul, Joyce, Tom, Greg, Chris B, and all the others who have worked so hard to turn these papers into a reality. Without the indirect contributions of Joyful, Janet, and indeed all of our moderators and members, we could not have made this huge step forward. My thanks to you all
Sincerely
Trevor
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Joyful
Foundation Staff
| Joined: | Sat Jun 9th, 2007 |
| Location: | USA |
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Posted: Sat Feb 21st, 2009 23:01 |
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Dr. Marshall,
After reading both of these new papers,
I have two words for you: Excellent work!
Congratulations & Thanks
to you and all the team. 
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MP Stories | Bacteriality | MP Search | MP Knowledge Base
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lpbryant
Member in Phase 3
| Joined: | Sun Feb 17th, 2008 |
| Location: | Australia |
| Posts: | 187 |
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Posted: Sun Feb 22nd, 2009 03:56 |
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I enjoyed reading these two articles.
And I do hope you are right that these articles will change "mainstream" doctor's opinions. I just hope they read them!
I will look forward to the publication in "Frontiers in Autoimmunity." Is this evalable to the lay-person or will we look for them on this site when they are ready?
Thanks again for everything,
Leah Bryant
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Sarcoidosis/lymph biopsy homozygous Factor V Leidens (hereditary blood clotting disorder),myalgia, hx PE 125D=32.69pg/ml 25D < 5.2 ng/ml warfarin freq INR w/home monitor Ph1May08
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Deedee
Member in Phase 2
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Posted: Sun Feb 22nd, 2009 04:01 |
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I am sharing this with everyone that I can. Thank you! Deedee
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Sarc in lymph nodes. D14. Back to Phase I, 100 mino Benicar 4X/day. Lipids high. 7/07 check-up: Normal PFTs/CXR improved; Quecentin/guaifensin if lymph nodes hurt. Spleen pains. Began MP 8/08
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kenc
Member in Phase 3
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Posted: Mon Feb 23rd, 2009 05:08 |
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These papers seem to be really well written. Good work! The picture just gets clearer and more complete with every release of another paper.
I have a question:
Beta-Defensin and cathelicidin antimicrobial peptides are described as broad-spectrum antibacterials in the paper "Vitamin D: the alternative hypothesis". Does this imply they have no effect on virus or fungi? Does the VDR transcribe any peptides that effect viruses and/or fungi?
Ken
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Crohn's Disease 1984, 24May05 1,25D=33 25D=8.4, 6Sep05 1,25D=29 25D=12, 11Jun07 25D=<10.4 1,25D=10, 15Sep07 1,25D=14.2 25D=16, 12Jul05 Phase1 + pred, 12Jul06 Phase2 + pred/dexa, 14Aug07 Phase2, prednisone, dexamethasone, testosterone, aspirin, levothyr
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Dr Trevor Marshall
Foundation Staff
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Posted: Mon Feb 23rd, 2009 05:30 |
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Does the VDR transcribe any peptides that effect viruses and/or fungi?
Yes. If you look through the Brahmachary paper you will find there are a number of the endogenous antimicrobials which target pathogens other than bacteria 
Brahmachary, M., et al. 2006. Computational promoter analysis of mouse, rat and human antimicrobial peptide-coding genes. BMC Bioinformatics. 7 Suppl
5: S8.
http://www.biomedcentral.com/1471-2105/7/S5/S8
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Martin78
Member in Phase 1
| Joined: | Sun Jul 15th, 2007 |
| Location: | Oslo, Norway |
| Posts: | 194 |
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Posted: Mon Feb 23rd, 2009 10:01 |
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I have read both papers and they are (according my abilities and judgement) well written, and marks an important breakthrough for all of us!
Great work and credos to all the people involved in the work! And with the knowlegde of even 3 or 4 more papers on the way this is a great start on 2009.
(...Lets not forget that is is donations to the ARF that makes this possible...)
BR
Martin
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Sjøgrens Syndrome|Fatigue|wt loss|itch|night sweats|pain|ancle|legs|ches|irritat|depr| hypercalcemia|initial 125D 98|Probe Apr08|Valium| 25D30 Jan15.09|Ph1 Jan15.09|visit my site: http://www.youngsjogrens.com
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Ron
Member in Phase 2
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Posted: Mon Feb 23rd, 2009 11:26 |
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Yes. Great work indeed and I too enjoyed reading both papers.
It surprised me a bit to read below Fig. 1 that "The two metabolites have nearly identical affinities for the VDR".
It seemed so logical in the presentation by Prof. Dr. Paul Lips (slide 4) last November:
affinity to VDR 25-D: very low 1,25-D: very high
since the concentrations of both metabolites differ by a factor 1000.
But when you think about it, if they indeed are nearly identical molecules, I guess they must also have nearly identical affinities to the VDR.
Does that make sense?
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Dad with RA, MP 01/08| 25D-16.8| Apr08 7.1 Sep08 11.6 Mar09 7.6 Jul09 17 Dec09 10.4| oxycodon, NoIRs, limited outings covered up
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Dr Trevor Marshall
Foundation Staff
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Posted: Mon Feb 23rd, 2009 16:19 |
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The affinity is due to forces of attraction between adjacent atoms in the molecules. The shape is the only thing which is important, and the two nearly-identically shaped molecules have nearly-identical affinities.
The concentration differences arise because physicians are not measuring concentrations in the cytoplasm of the cell, but in the blood. Within the cell, there is very little difference in the concentrations; 1,25-D is about 2 nanomolar.
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Ron
Member in Phase 2
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Posted: Mon Feb 23rd, 2009 19:49 |
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Now it makes sense again!
Thank you Dr. Marshall.
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Dad with RA, MP 01/08| 25D-16.8| Apr08 7.1 Sep08 11.6 Mar09 7.6 Jul09 17 Dec09 10.4| oxycodon, NoIRs, limited outings covered up
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Dogster
Member in Phase 3
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| Location: | Kansas USA |
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Posted: Wed Feb 25th, 2009 19:22 |
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"Does the VDR transcribe any peptides that affect viruses and/or fungi?" -- Yes, see Bramachary et al ....
Is this (in part) why you have said that as the innate immunity improves, so will the adaptive immunity-- and why, when a cfs patient asked you about Montoya's approach to the viral aspect you basically said not to bother . . .
(I think i am becoming living proof of this!!!!)
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CFS lyme RSD: pain migraine| tylenol fioricet flexeril tramadol temazepam| acidoph guaif/cold| Q| Cut D/exp Feb05| NoIR Mar05| June05 Comm Beni Q8H| July05 mino| Jan06 PH2| Aug06 1,25D=29 25D=17|
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Dr Trevor Marshall
Foundation Staff
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Posted: Wed Feb 25th, 2009 20:39 |
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Dogster wrote: Is this (in part) why you have said that as the innate immunity improves, so will the adaptive immunity-- and why, when a cfs patient asked you about Montoya's approach to the viral aspect you basically said not to bother
Yes, we have seen the body manage to deal with every insult. Once the immune system is restored, the human genome can start doing its work again, without interference from the plethora of microbial genomes.
See Amy's new paper:
http://AutoimmunityResearch.org/transcripts/AR-Proal-Metagenome.pdf
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Cynthia Schnitz
Member in Phase 3
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Posted: Thu Feb 26th, 2009 04:46 |
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| Wow, that's great. Did you say that a number of these recent articles are going to show up in a particular issue of a journal? Maybe it would be a good idea to buy the issue and give it to my doctor. It may be more effective given in that manor. Cynthia
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Ph1 10/08, Ph2 12/08, Ph3 6/09, 125/25D 47/43 preMP, 25D14 12/09, Estradiol .75mg, Calcium anomaly(gone?), Spondylitis, early Diverticulosis, early Macular Degeneration(AMD), Type II Diabetes (unconfirmed,PreDiabetes?), returning sense smell
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Aunt Diana
Moderator
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Posted: Thu Feb 26th, 2009 05:16 |
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| Good thinking, Cynthia!
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Lyme 1987, neuro cardio fatigue achiness brain fog depression, anxiety. Pacemaker, D.1,25 32; D <5; 12/07 <6, hydrocodone, lorazapam, benedryl, zantac, colase, Noirs, cover-up or avoid sun, house <30lux. Feb 08 Phase 3. 6/08 D <4, D1,25
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Dr Trevor Marshall
Foundation Staff
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Posted: Thu Feb 26th, 2009 08:59 |
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There is a special forthcoming issue of the Annals titled "Frontiers in Autoimmunity." It doesn't show yet on the Annals' web page:
http://www.nyas.org/annals/forthcoming.asp
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JENNYV
Health Professional
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Posted: Tue Mar 31st, 2009 16:58 |
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The articles are just what I was looking for - a perspective on the media's push of vit D supplementation. As an American concerned about health insurance's effect on the economy, I see the Vit D recommendations (and other public health misguided messages) as a health move that's going to rebound in excalating health care costs. While I want the US to have universal health care, I don't see how the public or private industry can afford the costs of the chronically ill - more people ill, and in more severe levels.
I work in the public health field as a dietitian in a food assistance program for young families. I've seen families where sickness tends to hit everybody. Over the 13 years I''ve worked, it seems like more people are sick and often multiple family members, and that severity levels are higher since a decade ago.
I want to write to my government and share my observations and own health triumphs and my concerns about health insurance and misdirected public health messages. Your articles will make the Vit D issues easy to explain. Jenny
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MP maintenance, NOIR-1/07-d/c~1/09, Benicar q8hrs 5/8/07, Mino 5/18/07, d/c Benicar & 3 antibiotics 10/08, migraines/allergy, unDx FMS/MCS, 12-06-dc D supp/food & 1,25D/25D=56/46, 3/07 25D=32, 6/07 25D=14, 3/09 1,25D/25D= 53/9
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Cynthia Schnitz
Member in Phase 3
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Posted: Thu Jul 23rd, 2009 03:47 |
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Dr Trevor Marshall wrote: There is a special forthcoming issue of the Annals titled "Frontiers in Autoimmunity." It doesn't show yet on the Annals' web page:
http://www.nyas.org/annals/forthcoming.asp
Hi Dr Marshall. Is this still in the works? Hope I haven't missed it. I looked over the last few months of offerings and didn't see it, so I'm guessing it is still in the works. Cynthia
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Ph1 10/08, Ph2 12/08, Ph3 6/09, 125/25D 47/43 preMP, 25D14 12/09, Estradiol .75mg, Calcium anomaly(gone?), Spondylitis, early Diverticulosis, early Macular Degeneration(AMD), Type II Diabetes (unconfirmed,PreDiabetes?), returning sense smell
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jcwat101
Research Professional
| Joined: | Tue Jul 20th, 2004 |
| Location: | Pasadena, USA |
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Posted: Thu Jul 23rd, 2009 04:07 |
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It is supposed to be published sometime in the fall.
Joyce Waterhouse
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20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 http://SynergyHN.com
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Cynthia Schnitz
Member in Phase 3
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Posted: Thu Jul 23rd, 2009 17:22 |
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| OK, patience. Thank you, Cynthia
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Ph1 10/08, Ph2 12/08, Ph3 6/09, 125/25D 47/43 preMP, 25D14 12/09, Estradiol .75mg, Calcium anomaly(gone?), Spondylitis, early Diverticulosis, early Macular Degeneration(AMD), Type II Diabetes (unconfirmed,PreDiabetes?), returning sense smell
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Bane
Member
| Joined: | Sun Jan 27th, 2008 |
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Posted: Fri Sep 18th, 2009 09:34 |
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jcwat101 wrote: It is supposed to be published sometime in the fall.
Joyce Waterhouse
Reversing Bacteria-induced Vitamin D Receptor Dysfunction Is Key to Autoimmune Disease:
http://www.ncbi.nlm.nih.gov/pubmed/19758226
Vitamin D metabolites as clinical markers in autoimmune and chronic disease:
http://www.ncbi.nlm.nih.gov/pubmed/19758177
Dysregulation of the vitamin D nuclear receptor may contribute to the higher prevalence of some autoimmune diseases in women:
http://www.ncbi.nlm.nih.gov/pubmed/19758159
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Oral Lichen Planus(mild)/Clubbed Finger (digital clubbing)Last 25D 5.6ng/ml, phase3
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