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Dr Trevor Marshall
Foundation Staff
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Posted: Thu Apr 30th, 2009 17:57 |
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I have proof-read the Science presentation and the MP presentation+MP questions. Is anybody working on transcribing the Q&A session for the Science presentation?
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paulalbert
Board Staff
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Posted: Thu Apr 30th, 2009 18:04 |
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I think this is wide open. Whoever does it, I'll check the spelling and put it up for you.
Paul
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Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
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Joyful
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Posted: Fri May 1st, 2009 04:40 |
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Oh! Sorry.
I transcribed the first question and the HIV video slide last night but didn't post them until just now... the questions are really hard to hear, but I'll finish up here with the last one shortly.
Edited to add:
The questions are transcribed as best as I could pick out the meaning between the background noise and interesting Prague accent.
Your answers, Dr. Marshall, were far easier to make out as I have become quite familiar with your special dialect of Southern (California) Australian! 
Last edited on Fri May 1st, 2009 10:23 by Joyful
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MP Stories | Bacteriality | MP Search | MP Knowledge Base
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wrotek
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Posted: Fri May 1st, 2009 12:28 |
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I like the presentation very much.
Especially enjoyed that HIV moves from one cell to another without entering space between cells- the movie in the end of presentation is great. I wonder, would making cells separated somehow , less agglutinated helped to slow down infection progression and improve treatment ?
Is there a good paper to read about how HIV uses VDR machinery for it's benefits ? Would love to read something about it.
Last edited on Fri May 1st, 2009 12:28 by wrotek
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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paulalbert
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Posted: Fri May 1st, 2009 12:31 |
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| Have a look at the KB's work in progress article on HIV/AIDS.
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Diag CFS 6.03 / sympt since 9.02 / exercise, food intol, sleep prob / 1,25D: 16, 4.06; 1,25D:27, 25D:26 7.04; 1,25D:43, 25D:6 6.05; 1,25D:17, 25D:8 8.05; / MP: 7.04 / Ph. 3 / Bacteriality
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wrotek
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Posted: Fri May 1st, 2009 12:52 |
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| thx
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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Dr Trevor Marshall
Foundation Staff
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Posted: Fri May 1st, 2009 13:23 |
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Thanks Joyful, Thanks Ron, Paul, and everyone. I have proof-read the Q&A session and have sent the transcripts and slides to Janet so that she can create the all-important hard-copy transcript to print for those Doctors who never touch a web browser 
Thanks, everybody. These two presentations, despite my bumbling around with words, will serve to let people know how far along we are in understanding the importance of the Th1 metagenomic microbiota to mankind
Later this month Amy will be giving a presentation on "Antibodies and Infection in the Era of the Metagenome" at the Intl Congress of Antibodies in Beijing. I will be accompanying her at the conference, I will be filming her talk, and will also traveling to West China Hospital to complete our planning there. Amy's presentation is something for us all to look forward to
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Joyful
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Posted: Sun May 3rd, 2009 08:39 |
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Dr. Marshall,
I thought your presentations were very good.
Due to our international audience, having you say the same thing a couple of different ways should be helpful to overcome the language barriers. That's how I perceived your manner of speech. (Not as bumbling.) But I know how awful it can feel to review your own presentations after the fact... always room for improvement.
However, from this somewhat 'critical' reviewer, I came away with a great respect for your ability to pull complex concepts together to "tell the story" and saw you as being very effective at bringing those concepts within reach of your audience. 
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MP Stories | Bacteriality | MP Search | MP Knowledge Base
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eClaire
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Posted: Sun May 3rd, 2009 18:14 |
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I will ditto Joyful in that. I think your ability to story tale the science and the MP is getting better and better, and I think this is an essential skill for catching the imagination of the intended audience (even doctors and researchers whom one would think this might not be necessary)!!
Claire
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38mo on MP; CFS FMS MCS COPD hypermob. IBS/GERD osteopor.; 125D48 25D<4;
NoIRs during most daylight outings & covered up; home w/o NoIRs
Ph1.Dec06 * ModPh2.Jun07 * AbxBrk.Mar-May08 * Ph2.Oct-Nov08 * Ph1.Jan2009
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Rico
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Posted: Fri May 8th, 2009 01:04 |
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Trevor, I've only listened to the Prague videos for the first time, this evening. I wonder how well your Infectious Disease/Metagenome presentation was taken? I mean, you said in so many words at a Clamydial Conference that they are wasting their time focusing on Clamydia co-infections rather than with intraphagocytic pathogens. Curious...
Very interesting, indeed.
Rico
Last edited on Fri May 8th, 2009 01:05 by Rico
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No diagnosis/some symptoms; wife with Sarc on MP; Olm 40mg q6h| avoid D| 1,25D=63 25D=32 (May 2006) 1,25D=44; 25D=10(Dec 2006)PhaseI(May06) PhaseII(Aug06) PhaseIII(Aug07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Fri May 8th, 2009 02:51 |
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At least part of the audience were suffering from Chlamydial infection, and looking for answers. I also felt that the physicians were looking for answers too. Remember they also invited Chuck Stratton (the Stratton Protocol) (Prof Sririam actually made the trip).
Why would they invite the MP and the SP if they weren't looking for answers?
I will be watching for signs of follow-up over the next few months
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jrfoutin
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Posted: Sun May 24th, 2009 05:10 |
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OK, the presentations are ready to look over and I sent them to Dr Marshall.
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Sarcoidosis 125D61, MP10/05 ModP2 12/05 Ph2 6/06 Ph3 10/06, NoIRs limited outings covered, 2/08 25D6.2, 10/08 25D6.9
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun May 24th, 2009 13:48 |
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Janet's transcripts are suitable for printing and giving to Doc. You can find them at:
http://AutoimmunityResearch.org/prague_2009/science.pdf
http://AutoimmunityResearch.org/prague_2009/MP.pdf
Thanks for doing these transcripts, Janet, Ron and all the others who helped
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eClaire
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Posted: Sun May 24th, 2009 18:35 |
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 JANET!!!
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38mo on MP; CFS FMS MCS COPD hypermob. IBS/GERD osteopor.; 125D48 25D<4;
NoIRs during most daylight outings & covered up; home w/o NoIRs
Ph1.Dec06 * ModPh2.Jun07 * AbxBrk.Mar-May08 * Ph2.Oct-Nov08 * Ph1.Jan2009
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Limburg
Member in Phase 2
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Posted: Sun May 24th, 2009 20:14 |
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Beautiful, Janet!  Last edited on Sun May 24th, 2009 20:15 by Limburg
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MS,DX 1997,Auto-immune hepatitis,DX 2008, MP start jan.2009. 25D: 20.4 (october 7,2009)25D: 12.5 (november 23,2009)
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Dody
Member in Phase 3
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Posted: Tue May 26th, 2009 16:54 |
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| This is so exciting. These two presentations (thank you Janet for the great transcriptions) are the best summaries I've seen yet. I will be printing both for docs and for seriously interested friends. --Dody
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Lyme Arrhythmia Vertigo Meningitis Bipolar lithium tylenol cover up outside mod low lux inside ModPh2Jul07 Ph2Apr08 Ph3Feb09 D25 Oct09 7 Mar10 4
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Caitiegirl
Member in Phase 2
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Posted: Tue May 26th, 2009 20:41 |
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Beautiful job everyone. I love the clinical aspects that are being addressed in the conferences this year. I can finally see the MP as a working protocol for mainstream medicine. I am working up packets to give not only Caitie's doc but to other doctors we see throughout our journey. Well done!
Mindy
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Caitlin(18) lyme, seizures, myoclonus, dystonia, digestive, chronic headache, mental fog: 10/23/07 25D 36 1,25D 58, 1/12/09/5.7, 1/18/08 25D 9.9 Cut sun/D 9/26/07 Benicar 10/25/07, NoIRs 10/29/07
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Frans
Member in Phase 2
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Posted: Sat Jun 6th, 2009 19:42 |
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Trevor,
You mention the study where M. Tubercolosis downregulated the VDR 3.3 fold.
I was wondering if we know which mechanism they utilise to do so ? Is it capnine ?
Best, Frans
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun Jun 7th, 2009 02:16 |
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Frans, the result is described in this study, although the mechanism is still unknown:
"Synergistic action of vitamin D and retinoic acid restricts invasion of macrophages by pathogenic mycobacteria"
http://www.ncbi.nlm.nih.gov/pubmed/18327422
I might add that the VDR seems to have some similar functions to PXR, FXR and the other newly discovered nuclear receptors, and I would be surprised if VDR down-regulation is the only effect present.
Capnine is a ligand, while the actual production of VDR itself is what was found to be down-regulated in the earlier M.tb study I cited in Prague. They used a micro-array to make their measurements. It is generally believed that the VDR itself is primarily transcribed by the newly-discovered Estrogen-receptor-beta
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