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ChrisMavo
Member
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Posted: Sun Feb 20th, 2011 20:10 |
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Thanks Fran!
I showed this study to my neurologist two days ago. She works at UCSF as do the researchers. She found my opinion interesting, that like this study, ALS is also caused by yet to be determined pathogens. More and more medical science is waking up to the fact that the microbiota causes many of the chronic diseases! I am confident that they will eventually find the same with ALS!
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PLS/ALS, speech difficulty, dizziness, leg weakness, overly emotional, Ph1Aug2609,11/2012 25D-12, 11/11: 25D-10, 04/11: 25D-11, 07/10: 25D-13, 05/10: 25D-15, 11/09: 25D-20, 9/09: 25D-27, 7/09: 25D-38, 1,25D-46, Mod Ph2Oct09, 100mg Mino
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Bane
Research Team
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Posted: Mon Mar 14th, 2011 15:16 |
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Our Body the Ecosystem: Understanding the Interplay Between Man and Microbe
http://tiny.cc/tthld
“In the last three decades, all of these allergic disorders—asthma, eczema, hay fever—they’ve all tripled,” Segre says. With that short of a time frame, the culprit can’t be simply changes in our own genome. “So it must be something about the gene-environment interaction. And I now believe that that’s modulated by the body’s bacteria.”
Segre doesn’t know whether bacteria associated with eczema are the cause of the disease or simply a consequence of living with it. To find out, she plans to perform a metagenomic analysis of the samples. During a metagenomic analysis, scientists compare thousands of genes present in a particular species’s DNA. By looking at the biological function of the genes—what kinds of proteins they make and what kinds of biological pathways those proteins are involved in—the scientists can make educated guesses about the role of each species, and how different species may work with one another and with our own genome.
“We all believe there’s an interdependency among these organisms. They’re highly dependent on their neighbors for their survival,” says Claire Fraser-Liggett, director of the Institute for Genome Sciences at the University of Maryland. Metagenomics, however, is immensely complicated. Researchers know little about how the millions of microbial genes might work together, and it’s difficult to sort out which patterns are signatures of disease versus part of normal variation between people. “There’s no way to overemphasize the analytical challenges,” Fraser-Liggett says. “It’s something that everybody is struggling with.”
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seanlane
Member
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Posted: Tue Mar 15th, 2011 02:14 |
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| Very interesting...
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bipolar CFS neuropathy arrhythmia food sensitivities psoriasis MCS guillain-barre tinnitus 125D58 Ph1Jul/08 Ph2Oct/08 25D=17.8 Sept/08 25D=11.8 Jul/09 Ph3 Sept/09
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Somatropin
Health Professional
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Posted: Fri Apr 1st, 2011 22:21 |
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Thanks Fran, this is a great article. I think more than anything, this illustrates the need for Asthmatics / IBS to brush their teeth and have excellent oral hygiene.
There have been strange relationships to people lacking H-Pylori to developing asthma / respiratory diseases. Could it be that H-Pylori is mis-understood? Does this 'bad' bacteria out-colonize other bacteria that are far worse?
Matt
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<b>*Somatropin*</b>
"Small improvements today have large implications for tomorrow"
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NickBowler
Member
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Posted: Tue Apr 12th, 2011 09:11 |
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http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2982.2010.01620.x/abstract
more on the mind/gut/microbiome connection
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Dr Trevor Marshall
Foundation Staff
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Posted: Tue Apr 12th, 2011 10:37 |
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The obesity results from Jeff Gordon at Washington U in mice did not transfer to man. Other groups have shown no link in man between gut species and obesity, even though it was clear in mice. When microbiota is involved, murine studies appear to be worthless.
..Trevor..
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Russ
Member*
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Posted: Tue Apr 12th, 2011 15:27 |
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| Does the MP change the composition of the microbes in the gut (i.e. which microbes dominate) or does it just reduce the overall amount of bacteria but the ratios remain the same?
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Dr Trevor Marshall
Foundation Staff
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Posted: Tue Apr 12th, 2011 17:41 |
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A paper in Vancouver showed that antibiotics change the relative concentrations of GI tract species. The bacteria were not totally wiped out by antibiotics. I imagine the human immune system would also tend to change the flora composition, in time.
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Marysue
Foundation Staff
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Posted: Tue Apr 12th, 2011 22:51 |
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It seems to me that the immune system, antibiotics, and diet would all play a role in the composition of gut bacteria over time during the recovery process.
Marysue
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MP Apr09 (no breaks)| CFS/FM,infert/endometriosis | hypotension, cardiac IP, chronic muscle/joint pain, neuro symptoms, severe light sensitivity | last 25D=12.5 Sep'11
Marysue on Benicar
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Bane
Research Team
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Posted: Thu Apr 21st, 2011 10:46 |
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Bacteria Divide People Into 3 Types, Scientists Say
http://www.nytimes.com/2011/04/21/science/21gut.html?_r=2
“It’s an important advance,” said Rob Knight, a biologist at the University of Colorado, who was not involved in the research. “It’s the first indication that human gut ecosystems may fall into distinct types.”
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Dr Trevor Marshall
Foundation Staff
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Posted: Thu Apr 21st, 2011 12:02 |
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The analysis behind this Doctor's statements to NY Times are flawed, IMO.
It is usually possible to use mathematics and statistics to beat any data into submission, which is what has happened here. I gave the raw data from the enterotype syudy in my two slides from the Vancouver presentation of Dr Arumugam in the March 26th web-conference.
The raw data shows that the species found in each of the world regions was totally different. While I agree with this data being re-examined on the basis of "what do the bacterial species do" I consider that the analysis used by EMBL is badly flawed, as a too simplistic approach to bacterial activities was used.
I give the key image below, please fetch the original info from Arumugam's pdf from Vancouver, as I am too busy to do that right now. Gut microbiota from different regions of the world are labeled AM (American) and JP (Japan) in the different columns. AMD is Acid Mine Drainage, WF is whalefall, EBPR is ebpr sludge, MN is farm soil:
Arumugam, et al, 2010. Bioinformatics, 26(23), 2977
Relevant URLs:
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature09944.html
http://www.bork.embl.de/Docu/Arumugam_et_al_2011/
http://www.nature.com/nature/journal/vaop/ncurrent/extref/nature09944-s2.pdf
http://www.nature.com/nature/journal/vaop/ncurrent/extref/nature09944-s1.pdf
http://www.nature.com/nature/journal/vaop/ncurrent/extref/nature09944-s3.pdf
http://www.nature.com/nature/journal/vaop/ncurrent/extref/nature09944-s4.pdf
Last edited on Thu Apr 21st, 2011 12:39 by Dr Trevor Marshall
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Bane
Research Team
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Posted: Sun Jun 5th, 2011 10:18 |
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BBC Interviews about the Human Microbiome
http://www.bbc.co.uk/programmes/b011jv8r
"New research has suggested that pathogenic microbes could be implicated in a whole host of diseases, including obesity, heart disease, cancer, Alzheimer's, arthritis and autism.
"We may find there are new links between the human microbiome and diseases that today we don't think of having any underlying microbial component," says Claire Fraser-Liggett, Director of the Institute for Genome Sciences at the University of Maryland"
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun Jun 5th, 2011 15:31 |
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Notable things in the BBC Interview:
at 26:00
"We as scientists are very good at studying what we know. But the unknown is out of reach, and what it may take .. is someone who just has what might seem like a crazy idea, but the means to pursue it, and find that there are new links between the human microbiome, and diseases that today we don't really think of as having any underlying microbiological component."
Interview with Karen Nelson at 9:00 into the clip
Claire Fraser-Liggett, at 24:03 she questions the utility of probiotics
But on the whole, she doesn't seem to "get it" just yet... I suspect that at least one of her students, the one that did the Fusobacter Manhattan Plot I cite in my latest presentations, has a better understanding than she does...
Lisa Proctor at the NHGRI is the main voice heard...
Interesting at 20:00 "because the women are all healthy when they enroll" then any disease can be detected as they continue sampling from that time. - Big error IMO, as they are looking at a very small subset of the total time the microbiota has been forming... (just a year or two in a lifetime).
ps: I had to use Internet Explorer to listen to the program. My Firefox didn't stream it properly.
pps: I am uploading my NeuroTalk 2011 presentation to YouTube right now....
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Bane
Research Team
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Posted: Tue Jun 7th, 2011 21:40 |
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Moving pictures of the human microbiome
http://genomebiology.com/2011/12/5/R50/abstract
http://genomebiology.com/content/pdf/gb-2011-12-5-r50.pdf
Understanding the normal temporal variation in the human microbiome is critical to developing treatments for putative microbiome-related afflictions such as obesity, Crohn's disease, inflammatory bowel disease and malnutrition. Sequencing and computational technologies however have been a limiting factor in performing dense time series analysis of the human microbiome. Here, we present the largest human microbiota time series analysis to date, covering two individuals at four body sites over 396 timepoints.
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Marysue
Foundation Staff
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Posted: Wed Jun 8th, 2011 06:41 |
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Thanks for sharing this. 
We find that despite stable differences between body sites and individuals, there is pronounced variability in an individual's microbiota across months, weeks and even days. Additionally, only a small fraction of the total taxa found within a single body site appear to be present across all time points, suggesting that no core temporal microbiome exists at high abundance (although some microbes may be present but drop below the detection threshold). Many more taxa appear to be persistent but non-permanent community members.
Perhaps statements like this will help us remember how dynamic the human-microbiota interaction is--constantly changing and never the same from one moment to the next.
Marysue
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MP Apr09 (no breaks)| CFS/FM,infert/endometriosis | hypotension, cardiac IP, chronic muscle/joint pain, neuro symptoms, severe light sensitivity | last 25D=12.5 Sep'11
Marysue on Benicar
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Cynthia Schnitz
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Posted: Wed Jun 8th, 2011 21:20 |
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| I wonder if the microbiota are fairly mobile. You'd think they would be exposed if moving around a lot. Cynthia
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Frans
Member*
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Posted: Thu Jun 9th, 2011 00:13 |
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Cynthia Schnitz wrote: I wonder if the microbiota are fairly mobile. You'd think they would be exposed if moving around a lot. Cynthia
or killed ..
you might want to look at figure 3 in the pdf Cynthia, it gives an insight into persistent and non-persistent parts of the microbiota, very interesting, them critters do get around
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Cynthia Schnitz
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Posted: Thu Jun 9th, 2011 03:42 |
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| I was disappointed to see that the sites for investigation only included external access locations, and I would guess that there were a large percentage of non-CWD bacteria being looked at. So, I guess mobile bacteria are mobile. Not too surprising. I actually am relieved to realize that they are not making the claim that CWD bacteria levels are highly changeable, which would be contrary to our experience, that they are killed off slowly in general, with our immune systems working on certain sites for months at a time. Cynthia
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MP start 10/08 (no breaks) | Spondylitis 97, early Diverticulosis 98, early AMD 08, Calcium anomaly 95, TypeII Diabetes(?) 02 | 25D=10.1ng/ml 12/12, (preMP 125D/25D=47/43) | My progress
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mvanwink5
Member*
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Posted: Thu Jun 9th, 2011 12:07 |
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Months? In my dreams. 
Mike
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Lyme joints, muscle pain, mood, brain fog, photosensitive, MP start 8/10; 25D 11ng/ml 5/13; vegetarian; no abx, Olm(no breaks) current dosage 160 mg/day, Guaifenesin before bed My Progress
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leroybrown
Board Staff
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Posted: Fri Jun 10th, 2011 15:44 |
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It tells me the pdf is damaged, but I was thinking maybe that is why IP is sometimes so unpredictable.
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Aplastic anemia Apr/10, PRCA Jan/09, Agranulocytosis 1991
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