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Dr Trevor Marshall
Foundation Staff
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Posted: Wed Mar 7th, 2012 09:06 |
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Who cares? And why?
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wrotek
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Posted: Wed Mar 7th, 2012 10:25 |
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| Well if the study is badly done and curcumin actually shuts down VDR, we would know to avoid it.
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Dr Trevor Marshall
Foundation Staff
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Posted: Wed Mar 7th, 2012 10:27 |
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I thought we had already decided to avoid it, except in small quantities as a spice in foods??
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wrotek
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Posted: Wed Mar 7th, 2012 10:31 |
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| Oh we did ? I did not know that. It never tasted good anyway, bitter dry sand. But i like Mustard ... Last edited on Wed Mar 7th, 2012 10:37 by wrotek
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Cynthia Schnitz
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Posted: Wed Mar 7th, 2012 19:34 |
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If amyloid beta is an antimicrobial peptide, does it make any sense for macrophages to be gobbling it up?
Mustard comes under the heading of seasoning. Tho I eat it in such quantities, I sometimes wonder.
Cynthia
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Dr Trevor Marshall
Foundation Staff
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Posted: Wed Mar 7th, 2012 20:06 |
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Cynthia,
Macrophages clean up general cellular junk and trash, and might perhaps clean up scraps of antimicrobial. In this case, whoever, the pathogens which caused the monocytes and macrophages to produce the amyloid-beta in the first place have almost certainly vanished in the process of the researchers trying to get access to the tissue, so all bets are off with respect to what actually might be happening a live human being 
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Chloe Ringer
Member
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Posted: Thu Mar 8th, 2012 15:54 |
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I'm reminded of a paragraph on biotechnology by Wendell Berry in his book, Citizen Papers:
"Richard Strohman, of the University of California-Berkeley, has proposed that the problems of biotechnology arise, not because the science is new, but because it is old. He sees it as a development of a now outdated paradigm according to which scientists have undertaken to supply simple solutions to complex problems, without due regard to the complexity of the problems. The proper scientific response to this, he says, is to enlarge the context of the work."
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lorenzo von matterhorn
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Posted: Tue Mar 13th, 2012 13:15 |
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http://www.newsroom.ucla.edu/portal/ucla/scientists-pinpoint-how-vitamin-229702.aspx
macrophages gobbling up Amyloid Beta..
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wrotek
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Posted: Sat Mar 31st, 2012 11:54 |
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| Interesting differences between curcumin and 1,25-D in this paper.
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mvanwink5
Member*
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Posted: Sat Mar 31st, 2012 16:55 |
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From the paperThe mechanisms behind the effects of 1a,25–dihydroxyvitamin D3 on phagocytosis were complex and dependent on calcium and signaling by the "MAPK" pathway, which helps communicate a signal from the vitamin D3 receptor located on the surface of a cell to the DNA in the cell's nucleus. I am not sure what they are saying here, are they really saying the VDR was on the cell surface membrane? These researchers need serious help in writing technical papers for clarity. I am not saying I am better, but I have never heard of the VDR being on the cell surface before.
The paper might have an interesting find if the difference in curcumin and 1,25D was only due to VDR stabilization differences as they assert, but I can't see that they showed that (though they seem to infer that). They utilized a technique based on mass spectrometry, which showed that 1a,25–dihydroxyvitamin D3 stabilized many more critical sites on the vitamin D receptor than did the curcuminoids.
Best regards,
Mike
PS Sometimes I wonder if these researchers would conclude police are the cause of crime because they are frequently found at the scene of crimes, and therefore we need to reduce how many policemen there are (amyloid beta is an amp)?
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Russ
Member*
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Posted: Sat Mar 31st, 2012 17:31 |
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mvanwink5 wrote: From the paperThe mechanisms behind the effects of 1a,25–dihydroxyvitamin D3 on phagocytosis were complex and dependent on calcium and signaling by the "MAPK" pathway, which helps communicate a signal from the vitamin D3 receptor located on the surface of a cell to the DNA in the cell's nucleus.
Is this implying that VDR activation is dependent on calcium?
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mvanwink5
Member*
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Posted: Sat Mar 31st, 2012 18:56 |
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Russ,
As I understanding the paper it is after the VDR agonist has docked that the Ca becomes involved.
Best regards,
Mike
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Dr Trevor Marshall
Foundation Staff
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Posted: Sat Mar 31st, 2012 19:01 |
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Don't dwell on these biology papers too much - this is a far more complex issue than any of these research groups have ever dreamed. Each only gives you a small glimpse into the actual mechanisms in play...
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Russ
Member*
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Posted: Sat Mar 31st, 2012 23:25 |
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| Interesting. Thanks.
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