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wrotek
Member in Phase 3
| Joined: | Fri Dec 31st, 2004 |
| Location: | Wroclaw, Poland |
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Posted: Wed Mar 11th, 2009 16:15 |
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New buzz on coffee: It's not the caffeine that raises blood pressure
http://tinyurl.com/dnf77h
http://news.bio-medicine.org/medicine-news-2/New-buzz-on-coffee-3A-Its-not-the-caffeine-that-raises-blood-pressure-6496-1/
Swiss scientists studying caffeine's effects in a small group of people report markedly elevated blood pressure and increased nervous system activity when occasional coffee drinkers drank a triple espresso, regardless of whether or not it contained caffeine. The results suggest that some unknown ingredient or ingredients in coffee not caffeine is responsible for cardiovascular activation, he explains. Coffee contains several hundred different substances. Last edited on Wed Mar 11th, 2009 16:16 by wrotek
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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Bane
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Posted: Fri Mar 13th, 2009 16:01 |
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wrotek wrote: Coffee and cigarettes composition starts to be very interesting in regard to vitamin D metabolism 
The Aryl Hydrocarbon Receptor Activator Benzo[a]pyrene Enhances Vitamin D3 Catabolism in Macrophages.
http://www.ncbi.nlm.nih.gov/pubmed/19244278
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Oral Lichen Planus(mild)/Clubbed Finger (digital clubbing)Last 25D 5.6ng/ml, phase3
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expate
Member in Phase 3
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Posted: Fri Mar 13th, 2009 19:52 |
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Wow, interesting... if it states what it is that I think it says, given that "ligand" and "catabolism" aren't really in my vocabulary.
 dette
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Hypervitaminosis D 1,25-D 52 pg/ml, 25-D 38 (4/08), 25-D 34 (8/08), 25-D 29 (10/08), 25-D 14 (3/09), 25-D 15: D3=15, D2<4 (6/09): all ng/ml, started Ph1 7/17/08, Ph2 11/4/08, Ph3 2/18/09. Covered up, but no facemask any longer. NoIRs. Home low light.
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jlunn247
Member in Phase 3
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| Location: | Michigan USA |
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Posted: Sat Mar 14th, 2009 10:26 |
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Smoking tobacco lowers d 1,25.
Now that's atomic good one wrotek.
Last edited on Sun Mar 15th, 2009 19:41 by Dr Trevor Marshall
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emphysema/ cfs/nerve pain/ 125D56 /25D16/Ph1Mar07 ModPh2Jun07/Ph2Nov07/pHase3Feb08/spiriva
dark sunglasses hands & face exposed/light physical herx.jan10
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wrotek
Member in Phase 3
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Posted: Sat Mar 14th, 2009 11:35 |
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Modulation of vitamin D signaling by AhR may represent a mechanism underlying cigarette smoking-related diseases.
lilke lung cancer ?
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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Chris
Moderator
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Posted: Sun Mar 15th, 2009 14:10 |
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BaP enhanced the hydroxylation of 1,25(OH)(2)D(3) by CYP24A1 in THP-1 cells. Thus, AhR activation by BaP stimulates vitamin D(3) catabolism.
All right, does this mean that smoking can reduce the problems of Hypervitaminosis-D? I think it is saying that BaP helps get rid of 1,25D. Which would support the notion that smoking is a form of self-medication.
1,25-Dihydroxyvitamin D(3) [1,25(OH)(2)D(3)], a potent ligand for the nuclear receptor vitamin D receptor (VDR), has been shown to decrease the risk of osteoporosis, some types of cancer, cardiovascular disease, suggesting an opposing effect of vitamin D(3)
The terminology here seems not to follow what I've read elsewhere. Elsewhere 'D2' and 'D3' refer to forms of 25D, that are converted to 1,25D in the body. So, is there a D3 form of 1,25D as well as a D3 form of 25,D?
-- Chris
Last edited on Sun Mar 15th, 2009 18:34 by Chris
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sarcoid diagnosed 1991, probably started 1983
D25/1,25: Mar04 17/80, Sep04 12/50, Nov04 8/23, Jan05 9/39 May05 6/27; in phase3; fevers, muscle pain, tinnitus, depression, mental-fog, IBS, carpal-tunnel, fatigue, osteopenia
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Frans
Member in Phase 2
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Posted: Sun Mar 15th, 2009 15:00 |
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Elsewhere 'D2' and 'D3' refer to forms of 25D, that are converted to 1,25D in the body. So, is there a D3 form of 1,25D as well as a D3 form of 25,D?
Chris,
Yes. Globally:
Ergosterol -> D2 -> 25D2 -> 1,25D2
Cholesterol -> D3 -> 25D3 -> 1,25D3
1,25 (OH2) D3 --> the OH2 between brackets are the two Hydroxyl (OH) groups.
In 25 (OH) D3 there is ony one hydroxyl group, so we could spell it 25 (OH1) D3
Hope this helps,
Frans
Last edited on Sun Mar 15th, 2009 15:02 by Frans
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Burn-out/nervous breakdown Jan01 125D 48 25D8.48 Ph1Nov06 ModPh2Jan07 Ph2Apr08 Cipramil Seroquel NoIRs lite exp r/t work cover up 25D3.9(Oct07)
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun Mar 15th, 2009 15:35 |
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Good find, Bane. This lines up with my anecdotal observations of symptom palliation in Sarcies. It would also explain the difference between effects of second-hand and mainstream smoke.
Note that health-care workers (esp. nurses) have a much higher rate of smoking than other professionals. Hmm...
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Ruth Goold
Health Professional
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Posted: Sun Mar 15th, 2009 15:48 |
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Oh, good work Wrotek. It took you a while but you managed to show we really shouldn't still be enjoying that morning cup of java. Let me go jump off a bridge now...
Just please don't pick on resveratrol next, I'm pretty darn sure that evening glass of wine is palliative, too... 
Ruth
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03/02/07 Ph 1 MP; 2001: Pulmonary sarc; 01/04/07: 125 D=110pmol/L(45.8 pg/ml)| 25D=20.8 ng/ml: 04/07 19.2: 07/07 11?: 09/07 16.5: 11/07 <10.0: 01/08 <10.0: 05/08 10 ng/ml. Ca. Elocom (ears). diphenhydramine 25 mg. Adidas EE glasses outside. NoIRs
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Martha
Health Professional
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Posted: Sun Mar 15th, 2009 19:19 |
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Does anyone know if marijuana is also an immune system modulator????
Best to everyone, Martha
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Scleroderma resumed MP Feb07 after 2 yr hiatus due to pregnancy D2512 & D12545 NoIRS D25-8 (Sep07) Ph2Feb08
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Dr Trevor Marshall
Foundation Staff
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Posted: Sun Mar 15th, 2009 19:43 |
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Martha,
That question is best asked in the Health Professionals' forum
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mercuryspice
Member in Phase 3
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Posted: Tue Mar 17th, 2009 01:20 |
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Could my progress be inhibited by my medium iced coffee almost everyday?
lisa
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Lyme 25d 11, 125D44 25D11 Ph1 Sep06 ModPh2Jan07 Ph2Oct 07 Ph3May08 motrin flexeril wellbutrin prozac ativan NoIRs lite exp r/t to school
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Alayne
Member in Phase 3
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Posted: Tue Mar 17th, 2009 05:35 |
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Re: Coffee and black tea
In case it's of interest...
I've pretty much avoided coffee for most of the MP. I can take a sip or two, then that's enough. It doesn't "feel" right when I drink filter coffee. I would drink a cup or two of weak black or green organic tea on and off in the morning.
However, about a month ago, I started drinking more tea. I'd found some decaf black tea that I like, so I ended up drinking about 4 cups of tea a day. About a week into that, I started drinking a heavenly mix of instant coffee (with whole raw milk and splenda). Seems the instant coffee didn't make me feel as instantly yucky as the "Starbucks" type.
Rather belatedly, I realized that I have felt like absolute crap for the past few weeks - along with a "life out of body" sensation. My DH as well. He started the morning coffee thing and I was also giving him a cup or two of decaf black tea a day.
Sooo, we both decided yesterday to drop the coffee and black tea (we've never really experimented much with anything else). I must say that I felt some better today. Him too. Or at least, not so "weird." And, we both slept a bit better last night (sleep has gone to absolute pot over the past few weeks).
It'll be interesting to see if this is all directly connected the topic of this thread and not "just" that sometimes overwhelming IP that comes with a new dose of Clindy.
RE: Tobacco
I smoked for many years when younger. I could NEVER stand the smell of smoke from others though. It'd make me feel ill. However, when I smoked myself, I felt better. I just blew the smoke out the window. Interesting that it could have been palliative - makes sense when I think about it because I would feel better. I would smoke even when feeling very ill. Hmmm.
I never had a smoker's cough. And the lung infections I caught from a young age on didn't diminish even after years of quitting cigs. On the other hand, I could breathe more deeply at higher altitudes without them.
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CFS/ME/FM 6/05:25D-34 1,25D-69, 11/07:25D-8 1,25-37, Sick 6-11 mos/yr x30+yrs. NoIRs/Avoid Sun/D/Use Zinc oxide. 11/17/05-Ph1, 5/06-MPh2, 12/06-MPh2#2, 6/07-MPh2#3,1/08-Ph2, 4/08-Ph3, 10/09-No ABX, NonMP Meds: Calc&Mag/Lysine
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mercuryspice
Member in Phase 3
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Posted: Tue Mar 17th, 2009 09:26 |
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looks like i'm going to have to give up my daily mcdonalds medium iced coffee. I hope I can drink iced tea at least.
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Lyme 25d 11, 125D44 25D11 Ph1 Sep06 ModPh2Jan07 Ph2Oct 07 Ph3May08 motrin flexeril wellbutrin prozac ativan NoIRs lite exp r/t to school
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mercuryspice
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Posted: Tue Mar 17th, 2009 09:28 |
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does anyone know about NT factor and how it can help with energy? is it contraindicated in the MP?
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Lyme 25d 11, 125D44 25D11 Ph1 Sep06 ModPh2Jan07 Ph2Oct 07 Ph3May08 motrin flexeril wellbutrin prozac ativan NoIRs lite exp r/t to school
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jlunn247
Member in Phase 3
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Posted: Tue Mar 17th, 2009 10:28 |
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Ala
RE: Tobacco
I smoked for many years when younger. I could NEVER stand the smell of smoke from others though. It'd make me feel ill. However, when I smoked myself, I felt better. I just blew the smoke out the window. Interesting that it could have been palliative - makes sense when I think about it because I would feel better. I would smoke even when feeling very ill. Hmmm.
I never had a smoker's cough. And the lung infections I caught from a young age on didn't diminish even after years of quitting cigs. On the other hand, I could breathe more deeply at higher altitudes without them.
My story is very similar i smoked cigarettes from 1999 till 2008 and still cant stop craving them.
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emphysema/ cfs/nerve pain/ 125D56 /25D16/Ph1Mar07 ModPh2Jun07/Ph2Nov07/pHase3Feb08/spiriva
dark sunglasses hands & face exposed/light physical herx.jan10
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mercuryspice
Member in Phase 3
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Posted: Tue Mar 17th, 2009 14:09 |
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| i quit smoking in 1994 when I got lyme disease. I still have cravings for it. Although i can't stand the smell yuck!!!
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Lyme 25d 11, 125D44 25D11 Ph1 Sep06 ModPh2Jan07 Ph2Oct 07 Ph3May08 motrin flexeril wellbutrin prozac ativan NoIRs lite exp r/t to school
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expate
Member in Phase 3
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Posted: Tue Mar 17th, 2009 15:15 |
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Don't get me started.  I will go to the grave wanting a cigarette even though I haven't allowed smoking in my house for 24 years and get grossed out being around people who've been smoking.
dette
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Hypervitaminosis D 1,25-D 52 pg/ml, 25-D 38 (4/08), 25-D 34 (8/08), 25-D 29 (10/08), 25-D 14 (3/09), 25-D 15: D3=15, D2<4 (6/09): all ng/ml, started Ph1 7/17/08, Ph2 11/4/08, Ph3 2/18/09. Covered up, but no facemask any longer. NoIRs. Home low light.
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NickBowler
Member in Phase 3
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Posted: Tue Mar 17th, 2009 15:35 |
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Never mind the coffee and the ciggies, hold the cookies!!
http://www.ncbi.nlm.nih.gov/pubmed/8055906
http://www.jbc.org/cgi/content/full/280/49/40901
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Sarcoirodis CIDP, MP start 11/07, NoIRs, 02/08 25D-8, Ph3 since 07/08|
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Aunt Diana
Moderator
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Posted: Tue Mar 17th, 2009 19:27 |
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| I wish I could understand one word of what they are saying!!
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Lyme 1987, neuro cardio fatigue achiness brain fog depression, anxiety. Pacemaker, D.1,25 32; D <5; 12/07 <6, hydrocodone, lorazapam, benedryl, zantac, colase, Noirs, cover-up or avoid sun, house <30lux. Feb 08 Phase 3. 6/08 D <4, D1,25
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