The Marshall Protocol Study Site > PROGRESS REPORTS [members in study cohort] > Phase One Alumni Forum > Chris in phase 1
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The Marshall Protocol Study Site > PROGRESS REPORTS [members in study cohort] > Phase One Alumni Forum > Chris in phase 1 |
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ChrisW Member in Phase 3 
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Olmesartan, 40mg, 6hrs: day 25 Minocycline, 25mg, 48hrs: day 12 Hi all, I've commenced the MP and haven't experienced any significant issues so far. Immunopathology has been felt on the 2nd day after Minocycline and has ranged from nothing some days to very mild psychological disturbances, flu symptoms, fatigue, heart palpitations and general aches. I’m avoiding all sunlight and limiting artificial light however, have not noticed any sensitivity. Olmesartan 40mg is taken at 6am, 12pm, 6pm and approx 10pm. Mino 25mg approx 8am/48h. Also taking Solgar Calcium, Magnesium & Boron at 500/200/1.5mg respectively 24h for critical osteoporosis. I plan to increase Minocycline to 50mg/48h in 2 days. “Hopefully” immunopathology will increase as 25D decreases from current 23.6ng/L. Cheers, Chris  |
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ChrisW Member in Phase 3
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Olmesartan, 40mg, 6hrs: day 29 Minocycline, 50mg, 72hrs: day 3 Mmm... some advice from the pro's please! Three days ago I increased the Mino dose to 50mg/48hrs. Unfortunately I didn't feel any immunopathology for the first 48hrs, so stretched it out to 72hrs. I'm half way through day three and have felt tired and some minor aches. My question is: should I continue with the Mino at 50mg/72hrs OR go back to 25mg/48hrs? I believe there was more of a reaction at the 25mg/48hrs dose however, if I'm to continue on this dose I may be stuck here for quite some time until my 25D drops. Any suggestions are greatly appreciated. Cheers, Chris  |
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VEZ R.N. Health Professional
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Thank you for the update Chris, It can take several days for a new dosage to kick in. It is not realistic to always expect an immediate reaction to a new dosage though sometimes you will experience this. The q48hr schedule is what the protocol recommends though some members do vary it for either increasing or decreasing symptoms. As you will learn in PHASE 1 DOCUMENT each person must assess and experiment with dosing times to maximize the treatment individually. Here is a helpful link: What should I know about Minocycline? has links to all mino details. Phase One is the training ground for getting the feel of your immune response, your symptoms - and for gaining personal experience in managing all aspects of MP, including adjusting your meds, avoiding light and D etc.. and posting your details is helpful in assessing your progress. Another good link: Why isn't the Marshall Protocol working? what am I doing wrong? Hang in there, VEZ  |
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ChrisW Member in Phase 3
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Hi Vez, Thanks for your advice and quick response. I'll stick with the 50mg dose for another week or so and report back. Cheers, Chris |
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ChrisW Member in Phase 3
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Olmesartan, 40mg, 6hrs: day 40 Minocycline, 75mg, 48hrs: day 1 Howdy, No additional immunopathology was noticed on the 50mg/72hr dosage, so I reverted to 48hr dosing after my last post. Overall the 50mg dose produced almost no immunopathology for me. I've increased to 75mg/48hrs today and also had my vit D levels retested. We'll see how this goes. Cheers, Chris Noted |
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ChrisW Member in Phase 3
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Olmesartan, 40mg, 6hrs: day 46 Minocycline, 75mg, 48hrs: day 6 Hi all, The first day of Mino at increased dose of 75mg/48hrs produced 3-4 hours of extreme tiredness, subsequent doses have produced various other symptoms (mainly flu like and general aches) to a much lesser degree. Still waiting on recent Vit D test results. Cheers, Chris |
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Foundation Staff . 
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Thanks for checking in. We are standardizing progress reporting to make monitoring and data collection easier. Please use this simple format each time you post a weekly report. Briefly list these details of your current situation only: MP meds: Include doses in mg (except Bactrim) & schedules for each, recent changes, number of days at current dose/schedule Palliative meds: Light exposure: Symptoms: List only those that are significant and recent. Indicate if any are intolerable. Comments: Questions: Please list your ongoing non-MP meds in your signature line. In your next report, only list the palliative non-MP meds you've taken for the week. This gives us a better picture of current symptom severity. List routine measures to prevent natural light exposure (NoIRs, covered up, sunscreen) in your signature line only. In your next report, just describe your sun exposure (e.g. 1 hr daily commute to work or 2 hr trip to doctor on Monday only or 2 hrs playing tennis outdoors on Friday) for the week. This provides a clue to the cause of any symptom increase. Rating your symptoms on a scale of 1-10 (1 meaning barely noticeable and 10 meaning 'call 911') is helpful. Rating them at their highest for the week paints a good picture of how you are doing since symptoms should be tolerable at all times. Once you have your feet on the ground in phase one, it's a good idea to experiment with minocycline and Benicar to see how they work for you. Extend the mino dosing schedule to every 72 hours to see if symptoms are dampened or if more immunopathology is provoked. And conversely, when symptoms peak (not necessarily intolerable), reduce or stop the mino dose to see if that dampens symptoms. You could also try taking lower-dose minocycline every six or 12 hours to see if mino has an anti-flammatory effect for you. When a symptom approaches intolerable try an extra Benicar to see if that measure is effective to quell the symptom. The resulting information can be added to your personal tool kit and could come in handy in the future if symptoms become intolerable and you need to adjust MP meds to manage immunopathology. Let us know how it goes........... |
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ChrisW Member in Phase 3
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MP meds: Olmesartan, 40mg, 6hrs: day 51 Minocycline, 25mg, 48hrs: day 11 Palliative meds: None Light exposure: Approx 6 hrs/week (on weekends) car travel, covered head to toe, gloves, hat, NoIR, zinc oxide suncream. Symptoms: Various very mild general symptoms as detailed above (2) Comments: New 25D test results 20/11/07 23.2 ng/mL (58 nmol/L) Previous 25D test results 27/08/07 23.6 ng/mL (59 nmol/L) Frustrating that my 25D hasn't budged over the last 3 months despite strict avoidance. Other new test results that were within normal ranges before MP, looks as if the MP may be having some effect: HCT, Low, 0.39, (0.40 - 0.54 l/l) Albumin, High, 52, (34 - 48 g/l) Globulin, Low, 19, (20 - 36 g/l) Ferritin, High, 525, (30 - 400 ug/l) Questions: Is it possible to progress to stage 2/3 with elevated 25D levels? Could sunlight/incidental radiation exposure be contributing to 25D levels? (My understanding from info on this site is that it does not) Many thanks, Chris Last edited on Sat Dec 1st, 2007 13:42 by ChrisW |
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Foundation Staff .
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You can progress to phase 2 with caution while your 25-D is slowly dropping. See Stores of D gradually drop. Natural light exposure, if extreme, might cause a slight rise in 25-D. Since most folks on the MP shield themselves from natural light, it is rarely an issue with 25-D. See Why does exposure to natural light increase symptoms? |
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ChrisW Member in Phase 3
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MP meds: Olmesartan, 40mg, 6hrs: day 60 Minocycline, 100mg, 48hrs: day 5 Palliative meds: None Light exposure: Approx 6 hrs/week (on weekends) car travel, covered head to toe, gloves, hat, NoIR, zinc oxide suncream. Symptoms: All very mild and manageable (3): Headache, stabbing pains throughout body, running nose, sneezing, tiredness. Comments: Thanks for the info Meg. I've increased to 100mg of Mino and experienced greatest symptoms on the first cycle as with past increases. All symptoms still very mild and manageable. Questions: None Cheers, Chris Noted |
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ChrisW Member in Phase 3
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MP meds: Olmesartan, 40mg, 6hrs: day 75 Minocycline, 100mg, 48hrs: day 19 Palliative meds: None Light exposure: Approx 6 hrs/week (on weekends) car travel, covered head to toe, gloves, hat, NoIR, zinc oxide suncream. Symptoms: All very mild and manageable (3): Headache, stabbing pains throughout body, running nose, sneezing, tiredness. Comments: Last day of Phase 1, onto Phase 2 tomorrow. Overall for me Phase 1 has been much easier than anticipated with minimal IP and no severe reactions. Fortunately I have not had to work prior to, or whilst on the Marshall Protocol. This has undoubtedly has made it much easier for me to cope with the treatment and life in general, being able to withdraw or sleep as needed. Unfortunately improvements have not been easy to determine with possibly only a small improvement in digestion. Symptoms remain much the same as before the Marshall Protocol. The most obvious explanation I can see for this is my elevated 25OH Vitamin D levels which have been stubbornly uncooperative in falling. Hopefully my 25OH Vitamin D drops and I start to see some significant symptom improvement as I work my way through Phase 2. I'll update this topic if there's any significant change in my condition. Wishing everyone all the best with their health and happiness, Chris Last edited on Fri Dec 28th, 2007 13:44 by ChrisW |
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ChrisW Member in Phase 3
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Marshall Protocol: day 292 Phase 3 Recently I received a request from another member at an earlier stage of MP treatment for an update on my progress. I’ve reposted here for others that may be interested: ------------------------------------------- My health has definitely improved from when I started the Marshall Protocol about 9 month ago however, the improvements have been more subtle and slower than I hoped for. Generally speaking I've felt worse whilst on the Marshall Protocol and only really felt better when I've taken a short break (like last week, I delayed one of the antibiotics for 6 days). I've come to realise and accept that recovery is going to be a very slow process. At this stage I expect that it will probably be another 9 months before I'm seeing significant improvements. Because of my previous treatment experiences and the research I've done regarding the Marshall Protocol I'm confident that it is the best and only chance I have to regain my health. Unfortunately it's going to take much longer than I'd like. From my experience people on the Marshall Protocol heal at a different rates and experience different symptoms along the way. My advice to new comers would be to expect to feel worse for an extended period (approx 12 months?) before things improve. ------------------------------------------- All the best, Chris |
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