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wrotek
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Posted: Tue Aug 17th, 2010 20:19 |
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http://www.ncbi.nlm.nih.gov/pubmed/18832438
Loss of vitamin D receptor produces polyuria by increasing thirst.Kong J, Zhang Z, Li D, Wong KE, Zhang Y, Szeto FL, Musch MW, Li YC. Department of Medicine and Committee on Molecular Metabolism and Nutrition, University of Chicago, Chicago, IL 60637, USA.
Abstract Vitamin D receptor (VDR)-null mice develop polyuria, but the underlying mechanism remains unknown. In this study, we investigated the relationship between vitamin D and homeostasis of water and electrolytes. VDR-null mice had polyuria, but the urine osmolarity was normal as a result of high salt excretion. The urinary responses to water restriction and to vasopressin were similar between wild-type and VDR-null mice, suggesting intact fluid-handling capacity in VDR-null mice. Compared with wild-type mice, however, renin and angiotensin II were dramatically upregulated in the kidney and brain of VDR-null mice, leading to a marked increase in water intake and salt appetite. Angiotensin II-mediated upregulation of intestinal NHE3 expression partially explained the increased salt absorption and excretion in VDR-null mice. In the brain of VDR-null mice, expression of c-Fos, which is known to associate with increased water intake, was increased in the hypothalamic paraventricular nucleus and the subfornical organ. Treatment with an angiotensin II type 1 receptor antagonist normalized water intake, urinary volume, and c-Fos expression in VDR-null mice. Furthermore, despite a salt-deficient diet to reduce intestinal salt absorption, VDR-null mice still maintained the increased water intake and urinary output. Together, these data indicate that the polyuria observed in VDR-null mice is not caused by impaired renal fluid handling or increased intestinal salt absorption but rather is the result of increased water intake induced by the increase in systemic and brain angiotensin II.
I have noticed i am thirsty very often( if not all the time), and that coffee increases my thirst too (tea does not do the same).
Last edited on Tue Aug 17th, 2010 20:23 by wrotek
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Joyful
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Posted: Wed Aug 18th, 2010 08:17 |
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Thanks for that Wrotek.
I've craved salt and am have been more thirsty since the start of my main symptoms.
This is an interesting connection. 
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wrotek
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Posted: Wed Aug 18th, 2010 11:23 |
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I have stumbled upon it exploring interesting hydration approach - http://www.watercure2.org , they eat sea salt, drink water and avoid diuretics like caffeine, alcohol.
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Lyme reflux chronic pain fatigue depression 125D36 Ph1Sep05 Ph2Oct06 Ph3Apr07 homebound in low lux NoIRs 25D<7 Oct06
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Verena
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Posted: Wed Aug 18th, 2010 18:41 |
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Hello Wrotek,
bet it is! Most of the folks I know with MS are keeping their little bottles of water in Handbags etc.
Best, Verena
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Migraine 1976 - 2011, Eye Inflammation 1992 - 2011, Multiple Sclerosis s. 2007, Benicar: Oct. 09, Phase 1: March 10, mod. Phase 2: Sept. 10, back to Phase 1 Dec. 10, Benicar only 40mg q4 Dec. 11. Benicar only q6 Feb. 12. D pre MP: 25: 19,6 ng/ml 1,25: 54,
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Marty.K
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Posted: Wed Aug 18th, 2010 19:15 |
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I think excessive thirst may be caused by low insulin especially in diabetes which is known to be a Th1 disease.
I get really thirsty after consuming foods high in sugar, or when I have a drink of alcohol which both interact with insulin to excrete extra sugar or alcohol.
Maybe the body's response to lack of insulin in diabetics is trying to compensate with extra fluids to excrete these substances.
I wanted to check my insulin levels to see if I'm right. Still haven't had the chance to get the test done. Perhaps there are other mechanisms as well which cause excessive thirst.
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MP Nov'09 (no breaks), Cryptogenic Cirrhosis AIH or PBC '03, Idiopathic thrombocytopenic purpura '03, 25D <4 Nov'11
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wrotek
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Posted: Thu Aug 19th, 2010 12:36 |
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Well ethanol causes hangover which is dehydration caused by ethanol blocking vasopressin.
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BIGDOG
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Posted: Mon Oct 25th, 2010 07:49 |
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Excessive thirst is a known symptom of hypervitaminosis D.
One of the new bizarre symptoms I experienced "post tipping point" aka, after the bugs got a hold of my body and its hormones, and I started to slide down.
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wrotek
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Posted: Mon Oct 25th, 2010 08:32 |
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How do You know ? From the study or personal experience ?
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Aunt Diana
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Posted: Tue Oct 26th, 2010 03:10 |
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| Ever since I first came down with Lyme disease I have always had a drink in my hand or nearby. I thought it was because I needed the caffeine since I was so tired all the time, but the truth is I was always thirsty. I still am. I always have a bottle of water or some other liquid nearby. I never thought of it in relation to the disease, but now the "light" went on.
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Lyme 1987, neuro cardio fatigue achiness brain fog depression, anxiety. Pacemaker, D.1,25 32; D <5; 12/07 <6, hydrocodone, lorazapam, benedryl, zantac, colase, Noirs, cover-up or avoid sun, house <30lux. Feb 08 Phase 3. 6/08 D <4, D1,25
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jcwat101
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Posted: Thu Oct 28th, 2010 16:21 |
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For me, excessive thirst has been a food sensitivity reaction -- it recurs occasionally during a certain phase of a food reaction (withdrawal reaction).
Joyce Waterhouse
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20 yrs with CFS/FM/Lyme/IBS, food sensitivities; 1,25D/25D 8/04:64/11 http://SynergyHN.wordpress.com
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Vicki SA
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Posted: Tue Nov 2nd, 2010 08:59 |
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I don't have excessive thirst but I do notice that I am thirstier if I have more IP/herx.
When the IP/herx is low, my water bottle next to my bed can go relatively untouched.
FWIW
Cheerio Vicki
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ME/CFS 2000, Splenectomy, 8/05 - 1,25D51,25D16.5, Ph1 12/05, Ph3 1/07, Zoton 15mg, 2010 - cover with light r/t Work 3/7, NoIRs, hat, cover well, May 2012 25D - 9.6
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k
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Posted: Tue Nov 2nd, 2010 10:45 |
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I definitely had excessive thirst when I had CFS. I would be regularly thirsty, and it would be either very uncomfortable or distressing to not be able to get a drink quickly when I was thirsty. I remember criticising cafes where the water glasses were small. Anyway, I NEVER went anywhere without a water bottle. And if I forgot it, I readily bought some water at the first opportunity.
I would also have particular periods of unquenchable thirst. I would drink and drink and drink (water) and still feel thirsty.
I definitely knew I was a lot better the first couple of times I went out and completely forgot to take my water bottle, and more particularly that it wasn't a big deal when I realised I had forgotten it.
I don't get thirsty nearly as much anymore (and haven't had any of those unquenchable thirst episodes in a long time) and drink less. (One nice advantage of which is not having to go to the bathroom all the time).
I can't say I've particularly noticed that I'm more thirsty when I herx, but I wouldn't be surprised if this was the case.
My experience!
cheers, k
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CFS menorrhagia & dysmenorrhoea anxiety depression paxil 600mg calcium daily Ph1.Oct07 Ph2.Feb08 Ph3.Sept08 BeniOnly.Aug09 MinoRestart.Dec09 |25D=50(Jul07) 23(Oct07) 13.2(Jan08) 12.8(Oct08) 10(Sept09) 12.8(Jun10) 12.4(May11) 8.3(Apr12)
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Marysue
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Posted: Tue Nov 2nd, 2010 22:56 |
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Excessive thirst is a known symptom of hypervitaminosis D.
One of the new bizarre symptoms I experienced "post tipping point" aka, after the bugs got a hold of my body and its hormones, and I started to slide down.
In my personal experience, I would agree with Bigdog here. Yes, dehydration and excessive thirst are both signs of excess 1,25-D, as reported by study participants and by personal experience.
I noticed an increase in this symptom each time my overall disease symptoms increased as well as whenever I had other exposures that are linked to a rise in 1,25-D (sun, daylight, heat, excessive computer/TV light, etc.)
There are other things that can cause excess thirst, but I have noticed that even other contributing factors are less likely to cause excess thirst as I continue to progress on the MP--which, IMO, correlates to less of a rise in 1,25-D as the bacterial load comes down.
Marysue
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MP Apr09 (no breaks)| CFS/FM,infert/endometriosis | hypotension, cardiac IP, chronic muscle/joint pain, neuro symptoms, severe light sensitivity | last 25D=12.5 Sep'11
Marysue on Benicar
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BIGDOG
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Posted: Wed Nov 3rd, 2010 11:06 |
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wrotek wrote:
How do You know ? From the study or personal experience ?
Both. I noticed the symptom as very distinct and not usual for myself. Polydypsia or excessive unquenchable thirst was a symptom I had and searched for. That lead me to a cross referenced hypervitaminosis D symptom list.
And, as they say, the rest is history. 
That symptom quickly resolved on the MP, now a year in, I make myself drink lots of water, to help flush Herx toxins... NOT because I have this bizarre unquenchable thirst.
As far as the science part goes, I'd be inclined to look at disruptions in the kidney as "cause".
 Last edited on Wed Nov 3rd, 2010 11:11 by BIGDOG
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Diet changed AUG09 / PH1 NOV09 / PH2 FEB10 /PH3 APR10 / OLM 40MGq6h / M100mg48h / Z125mg10d /C150mg48h / 25D 13ng NOV09 9ng DEC09 7ng FEB10 / 1,25D 18pg NOV09 20pg FEB10 / NO other meds / SUN OK
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