The Marshall Protocol Study Site > ABOUT THE MARSHALL PROTOCOL > ANNOUNCEMENTS AND NEWS > Report from EICS Conference 19 Nov 2004
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The Marshall Protocol Study Site > ABOUT THE MARSHALL PROTOCOL > ANNOUNCEMENTS AND NEWS > Report from EICS Conference 19 Nov 2004 |
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| Moderated by: Dr Trevor Marshall | ||
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Dr Trevor Marshall Research Team 
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EICS of Kansas City, MO, hosted the 2004 "Emerging Infectious Diseases" conference in Kansas City MO on November 19,2004. There was a pre-conference dinner on the 18th, at which Pat Smith (from the Lyme Disease Association) spoke. http://lymediseaseassociation.org/   I followed with a quick speech explaining to the delegates that it was important for them to focus on the "Marshall Pathogenesis," as too many folks were thinking only about the "Marshall Protocol." I then gave a quick runthrough of the paper I had presented earlier in Budapest. The slides from that presentation are available at this URL: http://autoimmunityresearch.org/autoimmunity2004/auto2004_slides.pdf My presentation also incorporated the data on NOD Mice Research I got from Prof Bach (from Paris) at the conference, data which confirms that the diseases we know as Th1 are most probably due to mutation of many human genes by a multiplicity of bacterial infections. The main conference was held on Friday, and here is a photo of the conference hall, which was pretty full (more than 100 paid-up delegates.)  (Click to see larger image)Presentations from Dr Ed Masters focused on species of Borrelia in MO, especially a new species which he has been tracking down. There were also presentations by Dr Zhu, Chief State Epidemiologist for the State of Missouri, and Dr Bill Salzer on Ehrlichiosis, Dr Howard Pue on West Nile Virus, Dr Gordon Christenson on CFS / ME and Fibromyalgia, and Dr Eddie Hendrick on Prion disease. Afterwards we wound down at a local BBQ restaurant.  (Click to see larger image)(From left: Dr Chuck Crist, Dr Brian Fallon, Dr Ed Masters, (unidentified), Dr Denny Donnell). But, in my opinion, the most important and detailed presentation was delivered by Dr Brian Fallon.  At ILADS Dr Fallon was unable to talk about the results from the $5 million, 4-year, NIH study he had conducted into Chronic Lyme therapy with IV Rocephin, but at this conference he gave us the detailed results, together with a request that we not publish the details until they appear in print next September. So here is my summary of only the key points: 1. Chronic Lyme is real, and is measurable with objective neurological and physical indicators 2. 10weeks of IV Rocephin makes the patients feel better, and returned their objectively measurable deficiencies towards 'health,' but the neural indicators relapsed within 3 months. Some of the skeletal and physical indicators retained some improvement. 3. MRI scans are no use whatsoever in diagnosing or tracking the disease. The Fallon study found that the MRI scans showed "MRI hyperintensity burden does not change between time 1 and time 2. Hyperintensities appear to represent fixed damage." IMO, the corollary is that that, at least based on the MRI data shown by Dr Fallon at this conference, IV Rocephin does not change any irreversible brain damage. "Fixed Damage" is likely a long-term phenomena, IMO, only loosely related to the symptoms. 4. SPECT scans are of little use without analysis way beyond the means of a typical physician. 5. In answer to a direct question, how did anticoagulants seem to help the neurolyme, Brian said that the changes are not vascular, that they are metabolic, and opined that anticoagulants are not likely to do any longterm good 6. This study was so meticulous that they even matched education level of patients and controls, as well as age and sex. Further, Dr Fallon's group found from SPECT data that the main metabolic changes in the brain were in the region of the Parahippocampal Gyrus. This is responsible for receiving sensory input from the outside world, integrating it, and projecting it onto the Hippocampus (memory) and Amygdala (fear, aggression, mood).The Insula was also affected. Further, the Para-Lymbic dysfunction noted on SPECT 1. disrupts attention, memory and learning 2. alters emotional response to sensory stimuli 3. distorts links between visceral states and mood, and may lead to increased stress responses 4. depresses the immune response and alters endocrine function 5. alters perception and emotional valence of pain, smell and taste Six of the 37 patients and 37 controls had significant adverse events during the trial, including two cases of serious thrombus, one MRSA infection and one Gall Bladder removal. This was an amazing presentation, and made the whole conference a memorable one for me. I felt as though I was part of history - now we know the data on IV Rocephin, so we can start focusing on the 'why' of how this therapy affects the body in chronic Lyme. My host for the conference was George Howell, and here is a photo of us during the BBQ feast. Thanks, George, this was a great conference, it is going to take me a long time to digest all I learned from it.  (Click to see larger image)..Trevor.. ps: On the way back to the airport, George and I stopped to see the renovation of Union Station in KC. The community has done an amazing job of converting it into restaurants, Children's Museums, IMAX theatre, and an historical museum. Walking in the front door one was surrounded by not only the grandeur of the restored building, but also the decorated festive trees and lights which are being collected there for donation to the needy. Truly an amazing restoration effort.  (Click to see larger image)Last edited on Mon Nov 22nd, 2004 21:14 by Dr Trevor Marshall |
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hodologica Member 
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Trevor, I couldnt be more interested in how they discerned that the Para-Lymbic dysfunction (noted on SPECT) depresses immune response. But I understand if you are busy or dont wish to reveal too much about Fallon's unpublished work. -Eric P.S. The amygdala disturbance makes sense of course vis-a-vis "lyme rage" and anxiety. Last edited on Mon Nov 22nd, 2004 20:10 by hodologica |
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Betty G. Member
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Trevor, thanks for the report & photos. I especially enjoyed seeing the photos of Dr. Crist, Brian Fallon, and our own George!! Looking good there George! Betty, Iowa |
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ShrnHml Member in Phase 2/3 
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Dr. Marshall.......I'm glad you enjoyed your conference in my home state of Missouri, even though I'm on the other side in St. Louis. TIA......Sharon Last edited on Thu Nov 25th, 2004 18:53 by |
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